標題: Total Synthesis of a Glycoglycerolipid from Meiothermus taiwanensis through a One-Pot Glycosylation Reaction and Exploration of its Immunological Properties
作者: Ghosh, Bhaswati
Lai, Yen-Hsun
Shih, Yu-Yin
Pradhan, Tapan Kumar
Lin, Chun-Hung
Mong, Kwok-Kong Tony
應用化學系
Department of Applied Chemistry
關鍵字: glycosylation;immunology;lipids;natural products;total synthesis
公開日期: 1-Dec-2013
摘要: The total synthesis of a glycoglycerolipid isolate of Meiothermus taiwanensis and its truncated structural analogues is reported. Our synthesis employed DMF-modulated and low-concentration glycosylation reactions for the construction of - and -glycosidic bonds in the absence of participating protecting groups. Further simplification of the synthesis was achieved by employing a low-concentration one-pot glycosylation procedure. Preliminary immunological studies showed that one of the truncated structural analogues suppressed the cytokine production of THP-1 monocytes.
URI: http://dx.doi.org/10.1002/asia.201300933
http://hdl.handle.net/11536/23229
ISSN: 1861-4728
DOI: 10.1002/asia.201300933
期刊: CHEMISTRY-AN ASIAN JOURNAL
Volume: 8
Issue: 12
起始頁: 3191
結束頁: 3199
Appears in Collections:Articles


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