標題: | Distribution and drug susceptibilities of Candida species causing candidemia from a medical center in central Taiwan |
作者: | Chang, Te-Pin Ho, Mao-Wang Yang, Yun-Liang Lo, Pai-Chang Lin, Pei-Sheng Wang, An-Huei Lo, Hsiu-Jung 生物科技學系 分子醫學與生物工程研究所 Department of Biological Science and Technology Institute of Molecular Medicine and Bioengineering |
關鍵字: | Amphotericin B;Azoles;Candida species;Candidemia;Drug susceptibility;Echinocandins |
公開日期: | 1-十二月-2013 |
摘要: | Invasive fungal infections have increased significantly in the past few decades because of the increase in high-risk populations. To investigate the distribution and drug susceptibilities of such infections, we analyzed all 152 Candida isolates causing candidemia from 2004 to 2006 at the China Medical University Hospital, a medical center in central Taiwan. Candida albicans was the most common species, accounting for 52.6 % of the isolates, followed by C. tropicalis (19.7 %), C. parapsilosis (14.5 %), C. glabrata (8.6 %), C. guilliermondii (3.9 %), and C. pelliculosa (0.7 %). All isolates were susceptible to amphotericin B, anidulafungin, micafungin, and voriconazole according to minimum inhibitory concentrations (MICs) after a 24-h incubation; 0.7 %, 6.6 %, and 7.9 % of isolates were resistant to amphotericin B, fluconazole, and voriconazole, respectively, after 48-h incubation. Both C. albicans and C. parapsilosis had high degrees of agreement for azoles between 24- and 48-h incubation periods, whereas C. glabrata (38.5-46.2 %) and C. tropicalis (56.7-63.3 %) did not. The majority of the isolates with high azole MICs displayed a trailing growth phenotype. Hence, the MICs of different drugs after 24-h incubation may be considered for prognosis of candidemia. |
URI: | http://dx.doi.org/10.1007/s10156-013-0623-8 http://hdl.handle.net/11536/23451 |
ISSN: | 1341-321X |
DOI: | 10.1007/s10156-013-0623-8 |
期刊: | JOURNAL OF INFECTION AND CHEMOTHERAPY |
Volume: | 19 |
Issue: | 6 |
起始頁: | 1065 |
結束頁: | 1071 |
顯示於類別: | 期刊論文 |