Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chang, Te-Pin | en_US |
dc.contributor.author | Ho, Mao-Wang | en_US |
dc.contributor.author | Yang, Yun-Liang | en_US |
dc.contributor.author | Lo, Pai-Chang | en_US |
dc.contributor.author | Lin, Pei-Sheng | en_US |
dc.contributor.author | Wang, An-Huei | en_US |
dc.contributor.author | Lo, Hsiu-Jung | en_US |
dc.date.accessioned | 2014-12-08T15:34:08Z | - |
dc.date.available | 2014-12-08T15:34:08Z | - |
dc.date.issued | 2013-12-01 | en_US |
dc.identifier.issn | 1341-321X | en_US |
dc.identifier.uri | http://dx.doi.org/10.1007/s10156-013-0623-8 | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/23451 | - |
dc.description.abstract | Invasive fungal infections have increased significantly in the past few decades because of the increase in high-risk populations. To investigate the distribution and drug susceptibilities of such infections, we analyzed all 152 Candida isolates causing candidemia from 2004 to 2006 at the China Medical University Hospital, a medical center in central Taiwan. Candida albicans was the most common species, accounting for 52.6 % of the isolates, followed by C. tropicalis (19.7 %), C. parapsilosis (14.5 %), C. glabrata (8.6 %), C. guilliermondii (3.9 %), and C. pelliculosa (0.7 %). All isolates were susceptible to amphotericin B, anidulafungin, micafungin, and voriconazole according to minimum inhibitory concentrations (MICs) after a 24-h incubation; 0.7 %, 6.6 %, and 7.9 % of isolates were resistant to amphotericin B, fluconazole, and voriconazole, respectively, after 48-h incubation. Both C. albicans and C. parapsilosis had high degrees of agreement for azoles between 24- and 48-h incubation periods, whereas C. glabrata (38.5-46.2 %) and C. tropicalis (56.7-63.3 %) did not. The majority of the isolates with high azole MICs displayed a trailing growth phenotype. Hence, the MICs of different drugs after 24-h incubation may be considered for prognosis of candidemia. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | Amphotericin B | en_US |
dc.subject | Azoles | en_US |
dc.subject | Candida species | en_US |
dc.subject | Candidemia | en_US |
dc.subject | Drug susceptibility | en_US |
dc.subject | Echinocandins | en_US |
dc.title | Distribution and drug susceptibilities of Candida species causing candidemia from a medical center in central Taiwan | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1007/s10156-013-0623-8 | en_US |
dc.identifier.journal | JOURNAL OF INFECTION AND CHEMOTHERAPY | en_US |
dc.citation.volume | 19 | en_US |
dc.citation.issue | 6 | en_US |
dc.citation.spage | 1065 | en_US |
dc.citation.epage | 1071 | en_US |
dc.contributor.department | 生物科技學系 | zh_TW |
dc.contributor.department | 分子醫學與生物工程研究所 | zh_TW |
dc.contributor.department | Department of Biological Science and Technology | en_US |
dc.contributor.department | Institute of Molecular Medicine and Bioengineering | en_US |
dc.identifier.wosnumber | WOS:000328287100008 | - |
dc.citation.woscount | 3 | - |
Appears in Collections: | Articles |
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