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dc.contributor.authorLiu, Chia-Hungen_US
dc.contributor.authorChang, Hao-Hanen_US
dc.contributor.authorLiang, Tung-Cheen_US
dc.contributor.authorHuang, Juinn-Daren_US
dc.date.accessioned2014-12-08T15:34:50Z-
dc.date.available2014-12-08T15:34:50Z-
dc.date.issued2013en_US
dc.identifier.isbn978-1-4799-1071-7en_US
dc.identifier.issn1933-7760en_US
dc.identifier.urihttp://hdl.handle.net/11536/23714-
dc.description.abstractSample preparation is an essential processing step in most biochemical applications. Various reactants are mixed together to produce a solution with the target concentration. Since reactants generally take a notable part of the cost in a bioassay, their usage should be minimized whenever possible. In this paper, we propose an algorithm, CoDOS, to prepare the target solution with many reactants using common dilution operation sharing on digital microfluidic biochips (DMFBs). CoDOS first represents the given target concentration as a recipe matrix, and then identifies rectangles in the matrix, where each rectangle indicates an opportunity of dilution operation sharing for reactant minimization. Experimental results demonstrate that CoDOS can achieve up to 27% of reactant saving as compared with the bit-scanning method in single-target sample preparation. Moreover, even if CoDOS is not developed for multi-target sample preparation, it still outperforms the recent state-of-the-art algorithm, RSMA. Hence, it is convincing that CoDOS is a better alternative for many-reactant sample preparation.en_US
dc.language.isoen_USen_US
dc.subjectBiochipen_US
dc.subjectdigital microfluidic biochip (DMFB)en_US
dc.subjectdilutionen_US
dc.subjectsample preparationen_US
dc.subjectreactant minimizationen_US
dc.titleSample Preparation for Many-Reactant Bioassay on DMFBs using Common Dilution Operation Sharingen_US
dc.typeProceedings Paperen_US
dc.identifier.journal2013 IEEE/ACM INTERNATIONAL CONFERENCE ON COMPUTER-AIDED DESIGN (ICCAD)en_US
dc.citation.spage615en_US
dc.citation.epage621en_US
dc.contributor.department電子工程學系及電子研究所zh_TW
dc.contributor.departmentDepartment of Electronics Engineering and Institute of Electronicsen_US
dc.identifier.wosnumberWOS:000331072100091-
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