標題: | Synthesis of uniform core-shell gelatin-alginate microparticles as intestine-released oral delivery drug carrier |
作者: | Huang, Keng-Shiang Yang, Chih-Hui Kung, Chao-Ping Grumezescu, Alexandru Mihai Ker, Ming-Dou Lin, Yung-Sheng Wang, Chih-Yu 電子工程學系及電子研究所 Department of Electronics Engineering and Institute of Electronics |
關鍵字: | Alginate;Gelatin;Intestinal-released;Microfluidic;Oral delivery drug carrier |
公開日期: | 1-二月-2014 |
摘要: | A core-shell gelatin-alginate composite used for intestine-released oral delivery drug carrier was synthesized through microfluidic technique. At the fixed continuous phase flow rate, the size of the core-shell gelatin-alginate microparticles increases with the dispersed phase flow rate, and monodispersity can be retained (the variation coefficient for the diameter distribution can be kept less than 10%). The fabricated microparticles could remain intact in gastric juice for at least 3 h, indicating that the gelatin core could be well protected by alginate shell in acid environment. However, the alginate shell of the microparticles would swell or collapse in alkali environment in half an hour, assuring the controlled drug release in intestinal juice. The fabricated uniform core-shell gelatin-alginate microparticles were potential as pH-responsive drug carriers. |
URI: | http://dx.doi.org/10.1002/elps.201300194 http://hdl.handle.net/11536/24046 |
ISSN: | 0173-0835 |
DOI: | 10.1002/elps.201300194 |
期刊: | ELECTROPHORESIS |
Volume: | 35 |
Issue: | 2-3 |
起始頁: | 330 |
結束頁: | 336 |
顯示於類別: | 期刊論文 |