標題: Genomic expression for rat model of damp obstruction in Chinese medicine: Application of microarray technology
作者: Huang, GS
Hong, MY
材料科學與工程學系奈米科技碩博班
Graduate Program of Nanotechnology , Department of Materials Science and Engineering
關鍵字: damp obstruction;microarray;elements;gene expression
公開日期: 2005
摘要: Damp obstruction refers to the stagnation of vital energy (qi) caused by dampness resulting in dysfunction of body and limbs movement, as well as impairment of spleen and stomach digestive function. Damp obstruction is the dampness-induced imbalance of five elements; thus it serves as an ideal model for genomic study using cDNA microarray. We have performed microarray analyses to major organs of damp-obstructed rats. Cluster analysis for the expression profiles of major organs indicated that spleen, stomach, and kidney respond to dampness differently from heart, liver, lung, and brain. Gene expression profile specific to each element or group of elements was also identified. Our results are consistent with the philosophy of Chinese medicine that the five elements, metal (lung), wood (liver), water (kidney), fire (heart), and earth (spleen and stomach) coordinate by subjugation or restriction to maintain a healthy, physiological state. This is the first time that a powerful genomic tool was applied to probe the ancient theory of Chinese medicine.
URI: http://hdl.handle.net/11536/25076
http://dx.doi.org/10.1142/S0192415X05003065
ISSN: 0192-415X
DOI: 10.1142/S0192415X05003065
期刊: AMERICAN JOURNAL OF CHINESE MEDICINE
Volume: 33
Issue: 3
起始頁: 459
結束頁: 474
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