标题: | Evolution of the yeast protein interaction network |
作者: | Qin, H Lu, HHS Wu, WB Li, WH 统计学研究所 Institute of Statistics |
公开日期: | 28-十月-2003 |
摘要: | To study the evolution of the yeast protein interaction network, we first classified yeast proteins by their evolutionary histories into isotemporal categories, then analyzed the interaction tendencies within and between the categories, and finally reconstructed the main growth path. We found that two proteins tend to interact with each other if they are in the same or similar categories, but tended to avoid each other otherwise, and that network evolution mirrors the universal tree of life. These observations suggest synergistic selection during network evolution and provide insights into the hierarchical modularity of cellular networks. |
URI: | http://dx.doi.org/10.1073/pnas.2235584100 http://hdl.handle.net/11536/27447 |
ISSN: | 0027-8424 |
DOI: | 10.1073/pnas.2235584100 |
期刊: | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA |
Volume: | 100 |
Issue: | 22 |
起始页: | 12820 |
结束页: | 12824 |
显示于类别: | Articles |
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