環胺基酸酯結合非對稱胺基保護在寡糖合成上的應用

完整後設資料紀錄

DC 欄位	值	語言
dc.contributor.author	林士哲	en_US
dc.contributor.author	Lin, Shih-Che	en_US
dc.contributor.author	蒙國光	en_US
dc.contributor.author	Mong, Kwok-Kong	en_US
dc.date.accessioned	2014-12-12T01:30:53Z	-
dc.date.available	2014-12-12T01:30:53Z	-
dc.date.issued	2009	en_US
dc.identifier.uri	http://140.113.39.130/cdrfb3/record/nctu/#GT079625567	en_US
dc.identifier.uri	http://hdl.handle.net/11536/42651	-
dc.description.abstract	本篇論文要報導芐基(benzyl group)取代的oxazolidinone和非對稱胺基保護(desymmetric amino protection)的應用性。我們應用此合成策略製備了一型和二型的乳糖胺，此方法不但容易操作而且有著極佳的產率。無論是在氮原子上面的芐氧羰(benzyloxycarbonyl group)和芐基，或是在氧原子上的芐基，都可以在溫和條件下的氫解反應(hydrogenolysis)中一併去除。接著我們合成出H型血基質(H blood group substrate)中的部分三醣結構，再度證明此一策略的應用性。	zh_TW
dc.description.abstract	Joined use of N-benzyl oxazolidinone and N-benzyl-N-benzyloxycarbonyl (N-BnCbz) desymmetric amino-protecting function is reported. The new synthetic approach enables the facile preparation of type 1 and type 2 LacNAc disaccharide in satisfactory yield. One-pot deprotection of N-BnCbz and O-benzyl ether is achieved by hydrogenolysis under mild conditions. Further application of this protection strategy realizes the synthesis of trisaccharide H blood group substrate.	en_US
dc.language.iso	en_US	en_US
dc.subject	環胺基酸酯	zh_TW
dc.subject	非對稱胺基保護	zh_TW
dc.subject	寡醣合成	zh_TW
dc.subject	氫解反應	zh_TW
dc.subject	一鍋化去保護	zh_TW
dc.subject	oxazolidinone	en_US
dc.subject	dysymmetric amino protection	en_US
dc.subject	oligosaccharide synthesis	en_US
dc.subject	hydrogenolysis	en_US
dc.subject	one-pot deprotection	en_US
dc.title	環胺基酸酯結合非對稱胺基保護在寡糖合成上的應用	zh_TW
dc.title	Joined Use of Oxazolidinone and Desymmetric Amino Protection in Application of Oligosaccharide Synthesis	en_US
dc.type	Thesis	en_US
dc.contributor.department	應用化學系碩博士班	zh_TW
顯示於類別：	畢業論文

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