藉由可調控氫鍵作用力控制仿生高分子自組裝行為與相行為之探討

Abstract

由於有趣的物理以及廣泛的應用潛力，超分子自組裝儼然成為目前高分子科學的研究主軸。當前研究最好的例子即是生物體中的DNA核甘酸鹼基對之互補作用力(核甘酸鹼基對結合高分子化學)，存在自然系的核甘酸鹼基對可當作超分子作用力起始材料。來自自然界的啟發，化學家徹底探討生物體之間具有環境響應的有序排列機制，可以改變不同的環境參數，例如溫度、PH值、氧化還原態或濃度，由此概念所發展出具有刺激響應的仿生高分子材料已廣泛運用在生醫材料。

Supramolecular self-assembly continues to be one of the most studied subjects in polymer science due to the interesting physical properties and the wide potential applications. The origin of current research on multiple hydrogen bonding motifs can be found in nature with the nucleobase pairs of DNA (for the use of nucleobases as supramolecular motifs in synthetic systems). The widespread occurrence of these base pairs in natural systems makes them readily available starting materials. Inspired by natural systems, chemists have explored the use of non-covalent interactions for the construction of supramolecular polymers resulting in responsive materials with properties that can be changed by varying the environmental parameters, such as temperature, PH, redox state or concentration. Thus, synthetic materials that change properties in response to local environmental stimuli with very similar attributes are often prepared for a broad range of biomedical applications.