完整後設資料紀錄
DC 欄位語言
dc.contributor.author黃秋淵en_US
dc.contributor.author黃國華en_US
dc.date.accessioned2014-12-12T01:51:53Z-
dc.date.available2014-12-12T01:51:53Z-
dc.date.issued2011en_US
dc.identifier.urihttp://140.113.39.130/cdrfb3/record/nctu/#GT079852517en_US
dc.identifier.urihttp://hdl.handle.net/11536/48229-
dc.description.abstractTraditionally regarded as supporting cells, glia cells are structurally and functionally poised as ideal sensors and regulators of local microenvironments. Emerging evidence suggests that glia have key roles in regulating neuronal development. The differentiated type of neuroblastoma glioma hybrid cell line, NG108-15, has widely used in in vitro studies instead of primary-cultured neurons. We culture NG108-15 cells on different sizes of nanodot arrays to examine how glia cells sense nanoenvironment stimulis and regulate neuronal development. Here we show that different nanodot size arrays change the number of neuroblastoma cells on unit area of glioma cells. Our results show that glia can sense nanoenvironment stimulis and response in different regulation of neuronal development. By examining gene expression, nanodot sizes also influence glia-mediated neuronal factor, such as Wnt3 and BDNF. Our results show that glia can sense nanoenvironment stimulis and response in different regulation of neuronal development. The nanodot arrays can serve as an appropriate tool for investigating glia-neuron interactions.zh_TW
dc.description.abstractTraditionally regarded as supporting cells, glia cells are structurally and functionally poised as ideal sensors and regulators of local microenvironments. Emerging evidence suggests that glia have key roles in regulating neuronal development. The differentiated type of neuroblastoma glioma hybrid cell line, NG108-15, has widely used in in vitro studies instead of primary-cultured neurons. We culture NG108-15 cells on different sizes of nanodot arrays to examine how glia cells sense nanoenvironment stimulis and regulate neuronal development. Here we show that different nanodot size arrays change the number of neuroblastoma cells on unit area of glioma cells. Our results show that glia can sense nanoenvironment stimulis and response in different regulation of neuronal development. By examining gene expression, nanodot sizes also influence glia-mediated neuronal factor, such as Wnt3 and BDNF. Our results show that glia can sense nanoenvironment stimulis and response in different regulation of neuronal development. The nanodot arrays can serve as an appropriate tool for investigating glia-neuron interactions.en_US
dc.language.isoen_USen_US
dc.subject神經細胞zh_TW
dc.subjectneuronen_US
dc.title奈米點陣列的尺寸對神經膠細胞調控神經細胞增生的影響zh_TW
dc.titleThe sizes of nanodot array influence glial regulation on neuronal proliferationen_US
dc.typeThesisen_US
dc.contributor.department材料科學與工程學系奈米科技碩博士班zh_TW
顯示於類別:畢業論文


文件中的檔案:

  1. 251701.pdf

若為 zip 檔案,請下載檔案解壓縮後,用瀏覽器開啟資料夾中的 index.html 瀏覽全文。