合成2-去氧α醣苷鍵的立體選擇性及連續性醣基化方法開發

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DC Field	Value	Language
dc.contributor.author	陳俊翰	en_US
dc.contributor.author	Chen, Jiun-Han	en_US
dc.contributor.author	蒙國光	en_US
dc.contributor.author	Mong, Kwok-Kong	en_US
dc.date.accessioned	2014-12-12T01:57:54Z	-
dc.date.available	2014-12-12T01:57:54Z	-
dc.date.issued	2012	en_US
dc.identifier.uri	http://140.113.39.130/cdrfb3/record/nctu/#GT079925544	en_US
dc.identifier.uri	http://hdl.handle.net/11536/49881	-
dc.description.abstract	我們將二甲基甲醯胺調控醣基化策略運用在2-去氧硫醣予體上，成功與多個帶有相同離去基團的赤道位硫醣受體及2-去氧硫醣受體耦合出alpha醣苷鍵。利用NMR-study順利觀測到中間體glucosyl imidinium triflate。並運用此法成功合成出含有三個alpha醣苷鍵的四醣。	zh_TW
dc.description.abstract	We applied DMF-modulated glycosylation to 2-deoxy-thioglycosyl donor to construct alpha glycoside with wide equatorial-OH thioglycosyl and 2-deoxy-thioglycosyl accepter, which contain the same leaving group. Used NMR-study to observe intermediate, glucosyl imidinium triflate successfully. Then finished the synthesis of tatrasaccharide which contain 3 alpha glycosidic bonds.	en_US
dc.language.iso	zh_TW	en_US
dc.subject	2-去氧醣	zh_TW
dc.subject	alpha選擇性	zh_TW
dc.subject	連續醣基化	zh_TW
dc.subject	預活化醣基化	zh_TW
dc.subject	寡醣合成	zh_TW
dc.subject	2-deoxy suger	en_US
dc.subject	alpha selectivity	en_US
dc.subject	iterative glycosylation	en_US
dc.subject	pre-activation glycosylation	en_US
dc.subject	synthesize oligosaccharide	en_US
dc.title	合成2-去氧α醣苷鍵的立體選擇性及連續性醣基化方法開發	zh_TW
dc.title	Development of Stereoselective and Iterative Glycosylation Method for Synthesis of 2-deoxy-α-glycosides	en_US
dc.type	Thesis	en_US
dc.contributor.department	應用化學系碩博士班	zh_TW
Appears in Collections:	Thesis