Full metadata record
DC FieldValueLanguage
dc.contributor.authorChen, Chih-Hauen_US
dc.contributor.authorChen, Wei-Yuen_US
dc.contributor.authorChen, Yu-Chieen_US
dc.contributor.authorLee, Ming-Juanen_US
dc.contributor.authorHuang, Chyuan-Deren_US
dc.contributor.authorChanda, Kaushiken_US
dc.contributor.authorSun, Chung-Mingen_US
dc.date.accessioned2014-12-08T15:07:58Z-
dc.date.available2014-12-08T15:07:58Z-
dc.date.issued2010en_US
dc.identifier.issn0004-9425en_US
dc.identifier.urihttp://hdl.handle.net/11536/6266-
dc.identifier.urihttp://dx.doi.org/10.1071/CH09298en_US
dc.description.abstractA chimeric oligonucleotide tetramer and hexamer were synthesized by the phosphoramidite approach using a 2+2 and 3+3 strategy, respectively. The concept of convergent synthesis provides an efficient route toward the synthesis of longer chimeric oligonucleotides, such as small interfering RNA oligonucleotides without the pollution of n - 1 or shorter failures. This methodology offers an efficient and economical way to scale-up the synthesis of high purity oligonucleotides for clinical trials and commercial uses.en_US
dc.language.isoen_USen_US
dc.titleConvergent Solution Phase Synthesis of Chimeric Oligonucleotides by a 2+2 and 3+3 Phosphoramidite Strategyen_US
dc.typeArticleen_US
dc.identifier.doi10.1071/CH09298en_US
dc.identifier.journalAUSTRALIAN JOURNAL OF CHEMISTRYen_US
dc.citation.volume63en_US
dc.citation.issue2en_US
dc.citation.spage227en_US
dc.citation.epage235en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000274933500010-
dc.citation.woscount1-
Appears in Collections:Articles