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dc.contributor.author陳怡佳en_US
dc.contributor.authorI-Chia Chenen_US
dc.contributor.author吳獻仁en_US
dc.contributor.authorHsien-Jen Wuen_US
dc.date.accessioned2014-12-12T02:24:01Z-
dc.date.available2014-12-12T02:24:01Z-
dc.date.issued1999en_US
dc.identifier.urihttp://140.113.39.130/cdrfb3/record/nctu/#NT880500005en_US
dc.identifier.urihttp://hdl.handle.net/11536/66149-
dc.description.abstract中文摘要 本論文分別利用雙環[2.2.1]庚烯衍生物,來進行臭氧裂解反應,合成出骨架上含有四個氧原子且側鏈具酯基之含氧籠狀化合物4和10,經水解後,成功地合成出側鏈具羥基之含氧籠狀化合物5和11。 利用側鏈具羥基及甲基之含氧籠狀化合物,進行一系列取代反應,成功地合成出側鏈取代基具硫化物、胺類、疊氮等不同官能基之含氧籠狀化合物 12, 13, 14, 15, 16, 17, 18 及20,另外亦順利地合成出雙含氧籠狀化合物21。 利用側鏈具羥基之含氧籠狀化合物,經化學解析法及動力學解析法,成功地合成出掌性含氧籠狀純物質。 本論文利用側鏈具硫代醚基及亞□基之含氧籠狀化合物13, 14, 28和29,來代替二甲基硫醚及DMSO試劑,進行Corey Kim氧化反應及Swern氧化反應,對一級醇、二級醇作氧化試驗。zh_TW
dc.description.abstractAbstract Oznolysis of bis-endo-g-keto of bicyclo[2.2.1]heptene derivatives in CH2Cl2 at -78℃ following by treatment with Me2S afforded different tetraoxa-cage compounds with ester group on the side chain. After hydrolysis, different oxa-cages with hydroxy group on the side chain can be obtained. Using the oxa-cage compounds with hydroxy and methyl groups on the side chain via a series of substitution reactions, we can synthesize oxa- and bisoxa-cages with different functional group (such as azido, sulfide and amino groups) on their side chains. The synthesis of chiral oxa-cage compounds has been accomplished by chemical and enzymatic resolutions. Attempts for the applications of oxa-cages 13, 14, 28 and 29 on Corey-Kim oxidation and Swern oxidation to primary and secondary alcohols have been made.en_US
dc.language.isozh_TWen_US
dc.subject籠狀化合物zh_TW
dc.subject掌性化合物zh_TW
dc.subject化學解析法zh_TW
dc.subjectCage compoundsen_US
dc.subjectChemical Resolutionen_US
dc.subjectChiral compoundsen_US
dc.title利用化學解析法來合成掌性四氧四縮醛之含氧籠狀化合物zh_TW
dc.titleSynthesis of Chiral Tetraacetal Tetraoxa-Cage Compounds by Chemical Resolutionen_US
dc.typeThesisen_US
dc.contributor.department應用化學系碩博士班zh_TW
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