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dc.contributor.authorLin, Chie-Chiehen_US
dc.contributor.authorKo, Fu-Hsiangen_US
dc.contributor.authorChen, Chun-Chien_US
dc.contributor.authorYang, Yuh-Shyongen_US
dc.contributor.authorChang, Feng-Chien_US
dc.contributor.authorWu, Chung-Shuen_US
dc.date.accessioned2014-12-08T15:08:48Z-
dc.date.available2014-12-08T15:08:48Z-
dc.date.issued2009-09-01en_US
dc.identifier.issn0173-0835en_US
dc.identifier.urihttp://dx.doi.org/10.1002/elps.200900120en_US
dc.identifier.urihttp://hdl.handle.net/11536/6728-
dc.description.abstractA miniaturized metal semiconductor metal photodetector was developed as the core detector for chemiluminescence biosensor. The biosensor utilized the semiconductor manufacturing to fabricate the 83 interdigitated patterns of 250-nm metal line and 278-nm space in 100 mu m x 100 mu m active region. The established real-time detector was operated at 0.4 V to ensure the maximal signal to background ratio of 3600 under illumination intensity of 1.46 mW/cm(2). A chemiluminescence in the miniaturized chamber was successfully proposed to determine the model protein concentration in real-time analysis. Before the emission of light from the catalytic reaction of substrate, the model protein of streptavidin bound to horseradish peroxidase was successfully immobilized onto the sensor surface through the high-affinity conjugate with biotin. The detection limit of 4.76 nM for streptavidin analysis was obtained under the calibration curve of linear range over 5-100 nM with correlation coefficient of 0.9999.en_US
dc.language.isoen_USen_US
dc.subjectBiosensoren_US
dc.subjectChemiluminescenceen_US
dc.subjectMetal semiconductor metal photodetectoren_US
dc.subjectModel protein analysisen_US
dc.titleMiniaturized metal semiconductor metal photocurrent system for biomolecular sensing via chemiluminescenceen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/elps.200900120en_US
dc.identifier.journalELECTROPHORESISen_US
dc.citation.volume30en_US
dc.citation.issue18en_US
dc.citation.spage3189en_US
dc.citation.epage3197en_US
dc.contributor.department材料科學與工程學系zh_TW
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Materials Science and Engineeringen_US
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000270446200011-
dc.citation.woscount7-
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