標題: | Turner syndrome phalangeal screening based on a two-stage linear regression concept |
作者: | Tiu, Chui-Mei Liu, Tzu-Chiang Hsieh, Chi-Wen Niu, Dau-Ming Chen, Jen-Dar Jong, Tai-Lang 電子物理學系 Department of Electrophysics |
關鍵字: | carpal angle;metacarpal sign;phalangeal length;Turner syndrome;two-stage screening method |
公開日期: | 1-八月-2009 |
摘要: | Background: Turner syndrome (TS) is a congenital chromosomal abnormality, resulting in short stature, short fourth metacarpal, and retarded skeletal maturation in children. The existing methods of diagnosis, which include carpal angle, metacarpal sign, and body mass index (BMI), cannot accurately diagnose TS. The authors propose a novel procedure for examining the hand skeleton to distinguish between normal individuals and patients with TS. Methods: This investigation was divided into two parts. In the first part, existing methods (evaluation of the metacarpal sign, measurement of the carpal angle, and determination of BMI) were used. Examination in the second part was based on the two-stage screening method (TSSM). In the first stage in TSSM, the ratio of the lengths of the distal-middle phalanges of the fifth digit was determined in normal subjects with average range of satisfactory body height and TS patients. A suitable cut-off was found on linear regression and used to divide the plot into TS patients and normal subjects. In the second stage, the normal section was transferred to another group based on bone and chronological ages. A greater number of patients were diagnosed with TS using this method. Finally, four cut-off parameters were determined on linear regression analysis. Results with optimal sensitivity and specificity were automatically obtained. Results: The combination of TSSM with optimal programming (sensitivity = 0.81 and specificity = 0.91) was satisfactory for diagnosing TS patients. Conclusion: TSSM can suitably evaluate growth of the hand skeleton to distinguish between normal individuals and patients with TS. |
URI: | http://dx.doi.org/10.1111/j.1442-200X.2008.02797.x http://hdl.handle.net/11536/6852 |
ISSN: | 1328-8067 |
DOI: | 10.1111/j.1442-200X.2008.02797.x |
期刊: | PEDIATRICS INTERNATIONAL |
Volume: | 51 |
Issue: | 4 |
起始頁: | 453 |
結束頁: | 459 |
顯示於類別: | 期刊論文 |