標題: Estimating low-toxic-effect concentrations in closed-system algal toxicity tests
作者: Chen, Chung Yuan
Wang, Yun Ju
Yang, Chao Fen
環境工程研究所
Institute of Environmental Engineering
關鍵字: Toxicity;Pseudokirchneriella subcapitata;NOEC;EC(10);QSAR
公開日期: 1-七月-2009
摘要: The no-observed-effect concentrations (NOEC) and EC(10) values for 108 organic compounds were estimated, using multiple endpoints (i.e., biopopulation, growth rate, and dissolved oxygen production), from previous data obtained by a closed-system algal toxicity test (test alga: Pseudokirchneriella subcapitata). These low-toxic-effect concentrations are valuable to risk assessment of chemicals and protection of the aquatic environment as such information is quite scarce in existing toxicological databases. Furthermore, based on limited amount of available data, we found that the risk of organic toxicants to phytoplankton may be severely underestimated by existing databases, which are primarily derived by the conventional batch technique. Good correlation relationships between NOEC (or EC(10)) and EC(50) values were established. For polar and nonpolar narcotics, quantitative structure-activity relationships (QSARs) based on hydrophobicity, and/or the lowest unoccupied molecular orbital energy (Elumo) were developed with satisfactory predictive powers. The above statistical relationships can be applied to derive a preliminary estimation for the low-toxic-effect levels for other (or new) organic compounds that has no toxicological data available. (C) 2009 Elsevier Inc. All rights reserved.
URI: http://dx.doi.org/10.1016/j.ecoenv.2009.02.011
http://hdl.handle.net/11536/7002
ISSN: 0147-6513
DOI: 10.1016/j.ecoenv.2009.02.011
期刊: ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Volume: 72
Issue: 5
起始頁: 1514
結束頁: 1522
顯示於類別:期刊論文


文件中的檔案:

  1. 000266759200026.pdf

若為 zip 檔案,請下載檔案解壓縮後,用瀏覽器開啟資料夾中的 index.html 瀏覽全文。