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dc.contributor.authorChou, Chih-Hungen_US
dc.contributor.authorChang, Wen-Chien_US
dc.contributor.authorChiu, Chih-Minen_US
dc.contributor.authorHuang, Chih-Changen_US
dc.contributor.authorHuang, Hsien-Daen_US
dc.date.accessioned2014-12-08T15:09:12Z-
dc.date.available2014-12-08T15:09:12Z-
dc.date.issued2009-07-01en_US
dc.identifier.issn0305-1048en_US
dc.identifier.urihttp://dx.doi.org/10.1093/nar/gkp264en_US
dc.identifier.urihttp://hdl.handle.net/11536/7023-
dc.description.abstractSynthetic Biology, a multidisciplinary field, is growing rapidly. Improving the understanding of biological systems through mimicry and producing bio-orthogonal systems with new functions are two complementary pursuits in this field. A web server called FMM (From Metabolite to Metabolite) was developed for this purpose. FMM can reconstruct metabolic pathways form one metabolite to another metabolite among different species, based mainly on the Kyoto Encyclopedia of Genes and Genomes (KEGG) database and other integrated biological databases. Novel presentation for connecting different KEGG maps is newly provided. Both local and global graphical views of the metabolic pathways are designed. FMM has many applications in Synthetic Biology and Metabolic Engineering. For example, the reconstruction of metabolic pathways to produce valuable metabolites or secondary metabolites in bacteria or yeast is a promising strategy for drug production. FMM provides a highly effective way to elucidate the genes from which species should be cloned into those microorganisms based on FMM pathway comparative analysis. Consequently, FMM is an effective tool for applications in synthetic biology to produce both drugs and biofuels. This novel and innovative resource is now freely available at http://FMM.mbc.nctu.edu.tw/.en_US
dc.language.isoen_USen_US
dc.titleFMM: a web server for metabolic pathway reconstruction and comparative analysisen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/nar/gkp264en_US
dc.identifier.journalNUCLEIC ACIDS RESEARCHen_US
dc.citation.volume37en_US
dc.citation.issueen_US
dc.citation.spageW129en_US
dc.citation.epageW134en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.department分子醫學與生物工程研究所zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.contributor.departmentInstitute of Molecular Medicine and Bioengineeringen_US
dc.identifier.wosnumberWOS:000267889100024-
dc.citation.woscount19-
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