有機固態氨氣感測器

Abstract

本篇論文以Poly(3-hexylthiophene-2,5-diyl)做為氨氣感測的材料，使用它製成高孔洞密度垂直式二極體元件，藉由偵測電流變化間接得知氨氣濃度，其感測極限可達50ppb。此元件有以下優點：高靈敏度、對氣體反應快速、室溫下即時感測、製造快速簡單、成本低廉。健康的人呼氣中氨濃度約278ppb，而肝硬化病人呼氣中氨濃度約745ppb，高孔洞密度垂直式二極體元件的感測極限小於50ppb，所以我們選擇將它應用在生物氣體感測上。 我們與台北榮總神經再生實驗室合作，將Sprague-Dawley成年母鼠做慢性肝病誘導，並使用高孔洞密度垂直式二極體元件偵測其呼氣氨值，藉此判斷肝臟受損情況。本實驗是目前已能辨識正常與中度急性肝臟損傷之呼氣氨訊息差異。本篇論文將針對慢性肝臟損傷做進一步研究，並且探討元件對氨氣反應的不穩定性及使用Poly(3-octylthiophene-2,5-diyl)改善後的結果。

We use Poly(3-hexylthiophene-2,5-diyl) as ammonia sensor material. It is made to high porous density vertical diode. We know the ammonia concentration from the variation current. The ammonia sensor has many advantages as below, high sensitivity (50 ppb), real-time detect at room temperature and low cost. The ammonia concentration is 278 ppb in health human and 745 ppb in cirrhotic patients. Therefore we use the device on biology experiment. Adult female Sprague-Dawley rats are used in this study. All procedures involved animals were reviewed and approved by the Institutional Animal Care and Use Committee of Taipei Veterans General Hospital, Taiwan. So far we can distinguish acute-induced rats from health rats. We, then, do further research into the chronic liver injury. Besides we use Poly(3-octylthiophene-2,5-diyl) to enhance the stability.