閉迴路癲癇偵測之生理訊號處理積體電路實現

Abstract

癲癇是一種常見的神經失調疾病，而全球有百分之一的人患有此疾病，但癲癇病患中有百分之三十的人無法用藥物去做有效的癲癇控制，因此，一個可植入式及可攜帶式的醫療式器材是對癲癇控制的一種方法。 在此篇論文，提出了兩個分別由ASIC-based和RISC-based所實現的癲癇偵測器去實現及時性的閉迴路癲癇偵測演算法，第一個由ASIC-based所實現一個擁有無線資料傳輸功能的癲癇偵測器，是使用台積電0.18μm CMOS製成實現，並且做了動物實驗去驗證整個晶片系統，而第二個油RISC-based所實現一個擁有有線脈衝響應濾波器的癲癇偵測器，是使用台積電90 nm CMOS製成實現，在多通道的癲癇偵測運作時，此RISC-based的晶片比起第一個ASIC-based的晶片可消耗較少的能量。

Epilepsy is one of the most common neurological disorders, by which around 1% of the people in the world are affected. Unfortunately, 30% of the epilepsy patients cannot be treated sufficiently by antiepileptic drugs. As a result, a suitable implantable and portable medical device is a solution for epilepsy seizure control. To address these issues, an ASIC-based seizure detector and a RISC-based seizure detector are proposed to realize real-time closed-loop seizure detection algorithm. The ASIC-based seizure detector with wireless signal transmission is implemented in 0.18μm CMOS process and verified by animal experiment. The RISC-based seizure detector with FIR filter is implemented in 90 nm CMOS process and dissipates lower power compared with ASIC-based SoC when multi-channel seizure detection is realized.