親核試劑與炔類化合物進行麥可共軛加成反應之探討

Abstract

本篇論文主要是利用不同親核試劑與烯炔類及多炔類化合物進行共軛加成反應，去探討其反應路徑及加成的位向選擇，進而得到高效率的親核加成方式。本文將會探討最佳化反應條件，接著更換起始物上的取代基去進行反應，探討其推拉電子效應以及立體結構對反應性的影響。之後進行光譜分析，另外也利用二維核磁共振光譜、NOE獲得該化合物結構。

In this thesis, we study reactivity of conjugate addition with different nucleophiles toward enyne and polynes and then get an efficient way of nucleophilic addition. We optimize the reaction conditions, and study reactivity scope variously substitated enynes and polynes.As well as effects of electron-withdrawing functionality and three-dimensional structure on reactivity.The spectroscopic techniques, NMR, IR, MASS, two-dimensional NMR spectroscopy and NOE were used to identify the compound structure.