標題: | Non-lethal Candida albicans cph1/cph1 efg1/efg1 mutant partially protects mice from systemic infections by lethal wild-type cells |
作者: | Yang, Yun-Liang Wang, Chih-Wei Chen, Chiung-Tony Wang, Min-Hsien Hsiao, Chin-Fu Lo, Hsiu Juny 生物科技學系 Department of Biological Science and Technology |
關鍵字: | Candida albicans;Mouse model;Protection;Virulence |
公開日期: | 1-Mar-2009 |
摘要: | Although Candida albicans cph1/cph1 efg1/efg1 mutant cells are not lethal to mice, they proliferated in infected mice instead of simply being cleared by the host immune system. Here, we have shown that the cph1/cph1 efg1/efg1 mutant partially protects mice from systemic infections by the lethal wild-type Candida albicans cells. Our results further indicate that a second dose of the cph1/cph1 efg1/efg1 mutant did not boost the degree of protection. (c) 2008 The British Mycological Society. Published by Elsevier Ltd. All rights reserved. |
URI: | http://dx.doi.org/10.1016/j.mycres.2008.11.016 http://hdl.handle.net/11536/7580 |
ISSN: | 0953-7562 |
DOI: | 10.1016/j.mycres.2008.11.016 |
期刊: | MYCOLOGICAL RESEARCH |
Volume: | 113 |
Issue: | |
起始頁: | 388 |
結束頁: | 390 |
Appears in Collections: | Articles |
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