微循環影像血壓之研究

Abstract

人生最大的財富是健康，在三高的指標上本研究著重在血壓，希望藉由無加壓的方式來達到血壓的測量，從甲襞微血管著手，透過記錄影像來得知血流波訊號，再從血流波與血壓波的關係當中來推測血壓的數值。 本研究分成兩個部份，微循環與血壓。微循環的測量使用的是實驗室自製的儀器，透過儀器得到光體積描述訊號，經過經驗模態分解來去除基線漂移的現象，進而得到微循環指標，借由指標的變化來得知不同物品對人體臉部的微循環的作用為何；血壓的測量使用的是甲襞顯微鏡，透過錄製影片再將其轉為訊號來分析，首先分辨出影片中模糊的片段，再以單調性三次方內插法將移除的模糊片段連接起來，接著使用晃動影響消除法來移除人為晃動對訊號所造成的雜訊，最後再利用訊號所得到的特徵值來計算血壓值。 未來希望能將此方法應用於其他影片上而非侷限於甲襞，在實驗中，已經能夠使用手機所量測的影片來測得心跳，也就是說，如果能用手機所量測的影片來測得血壓，那就能用手機應用程式來實現這個目標，也就能讓無加壓的血壓量測方式普及到有智慧型手機的每個人。

The greatest wealth is health. This study focuses on blood pressure of three high indicators. It is a hope that blood pressure can be measured without applying pressure. The method approaches from the nailfold capillaries to obtain blood flow wave signals by recording images. Then infer the value of blood pressure from the relation between blood flow wave and blood pressure wave. This study is divided into two parts, the microcirculation and blood pressure. The self-made instrument is used in the measurement of microcirculation and photoplethysmography (PPG) signals are obtained. The phenomenon of baseline wander is removed by empirical mode decomposition (EMD). Then the microcirculation index is obtained. Through the change of the index, it will be known that how different items work on microcirculation of human's face; The nailfold microscope is used in the measurement of blood pressure and signals obtained from the recording films will be analyzed. First, the blurred segments of the film is distinguished. Second, connect the removed blurred segments by the monotonic cubic interpolation method. Third, motion artifact reduction is used to eliminate the noise caused by shaking. Finally, calculate the value of blood pressure by the obtained characteristics. In the future, this method is respected to be applied on other films rather than limited to nailfold films. In the experiment, the heart rate can be measured by the cell phone films. In other word, if the blood pressure can be measured by cell phone films, the goal of cuffless blood pressure measurements can be achieved by an app and then spread to everyone with smartphones.