標題: | A High-Sensitivity CMOS-Compatible Biosensing System Based on Absorption Photometry |
作者: | Chang, Yu-Wei Yu, Ping-Chun Huang, Yang-Tung Yang, Yuh-Shyong 生物科技學系 電子工程學系及電子研究所 Department of Biological Science and Technology Department of Electronics Engineering and Institute of Electronics |
關鍵字: | Biomedical transducers;CMOS analog integrated circuits;medical diagnosis;optical receivers |
公開日期: | 1-一月-2009 |
摘要: | An optical biosensing system based on a standard CMOS technology and absorption photometry is proposed. Within the compact prototype, a CMOS sensor consisting a P(+)/N(well) finger photodiode and a transimpedance amplifier was implemented in a standard 0.35-mu m CMOS technology. The ABTS/H(2)O(2)/HRP method was adopted to be coupled with various analytes of interest, such as glucose and histamine, which can serve as the basis for medical diagnosis. The experimental results demonstrate that the minimum concentrations successfully detected for H(2)O(2), glucose, and histamine are 1 mu M, 1 mu M, and 10 mu M, respectively. The detection limits are at least one order of magnitude better than those of reported CMOS biosensors, and are even comparable to those of a commercial spectrophotometer. |
URI: | http://dx.doi.org/10.1109/JSEN.2008.2011079 http://hdl.handle.net/11536/7764 |
ISSN: | 1530-437X |
DOI: | 10.1109/JSEN.2008.2011079 |
期刊: | IEEE SENSORS JOURNAL |
Volume: | 9 |
Issue: | 1-2 |
起始頁: | 120 |
結束頁: | 127 |
顯示於類別: | 期刊論文 |