標題: | Chaotropic salts: Novel modifiers for the capillary electrophoretic analysis of benzodiazepines |
作者: | Su, Hsiu-Li Lan, Min-Tsu Hsieh, You-Zung 應用化學系 Department of Applied Chemistry |
關鍵字: | affinity capillary electrophoresis;benzodiazepine;chaotropic salt;capillary electrophoresis;ionic liquid |
公開日期: | 1-八月-2008 |
摘要: | This paper describes a CE method for analyzing benzodiazepines using the chaotropic salts lithium trifluoromethanesulfonate (LiOTf), lithium hexafluorophosphate (LiPF6), and lithium bis(trifluoromethanesulfonyl)imide (LiNTf2) as modifiers in the running buffer. Although adequate resolution of seven benzodiazepine analytes occurred under the influence of each of the chaotropic anions, the separation efficiency was highest when bis(trifluoromethanesulfonyl)imide (Tf2N-) was the modifier. We applied affinity CE in conjunction with linear analysis to determine the association constants for the formation of complexes between the Tf2N- anion and the benzodiazepines. According to the estimated Gibbs free energies, the interactions between this chaotropic anion and the benzodiazepines were either ion-dipole or ion-induced dipole interactions. Adding chaotropic salts as modifiers into CE buffers is a simple and reproducible technique for separating benzodiazepines. |
URI: | http://dx.doi.org/10.1002/elps.200800073 http://hdl.handle.net/11536/8514 |
ISSN: | 0173-0835 |
DOI: | 10.1002/elps.200800073 |
期刊: | ELECTROPHORESIS |
Volume: | 29 |
Issue: | 16 |
起始頁: | 3384 |
結束頁: | 3390 |
顯示於類別: | 期刊論文 |