標題: RNALogo: a new approach to display structural RNA alignment
作者: Chang, Tzu-Hao
Horng, Jorng-Tzong
Huang, Hsien-Da
生物科技學系
生物資訊及系統生物研究所
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
公開日期: 1-Jul-2008
摘要: Regulatory RNAs play essential roles in many essential biological processes, ranging from gene regulation to protein synthesis. This work presents a web-based tool, RNALogo, to create a new graphical representation of the patterns in a multiple RNA sequence alignment with a consensus structure. The RNALogo graph can indicate significant features within an RNA sequence alignment and its consensus RNA secondary structure. RNALogo extends Sequence logos, and specifically incorporates RNA secondary structures and mutual information of base-paired regions into the graphical representation. Each RNALogo graph is composed of stacks of letters, with one stack for each position in the consensus RNA secondary structure. RNALogo provides a convenient and high configurable logo generator. An RNALogo graph is generated for each RNA family in Rfam, and these generated logos are accumulated into a gallery of RNALogo. Users can search or browse RNALogo graphs in this gallery to receive additional perspectives of known RNA families. RNALogo is now available at: http://rnalogo.mbc.nctu.edu.tw/.
URI: http://dx.doi.org/10.1093/nar/gkn258
http://hdl.handle.net/11536/8629
ISSN: 0305-1048
DOI: 10.1093/nar/gkn258
期刊: NUCLEIC ACIDS RESEARCH
Volume: 36
Issue: 
起始頁: W91
結束頁: W96
Appears in Collections:Articles


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