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dc.contributor.authorTsao, Kuo-Chienen_US
dc.contributor.authorKuo, Yung-Binen_US
dc.contributor.authorHuang, Chung-Gueien_US
dc.contributor.authorChau, Shao-Wenen_US
dc.contributor.authorChan, Err-Chengen_US
dc.date.accessioned2014-12-08T15:11:38Z-
dc.date.available2014-12-08T15:11:38Z-
dc.date.issued2011-05-01en_US
dc.identifier.issn0166-0934en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.jviromet.2011.02.009en_US
dc.identifier.urihttp://hdl.handle.net/11536/8923-
dc.description.abstractThe early detection of pandemic influenza strains is a key factor for clinicians in treatment decisions and infection control practices. The aims of this study were to determine the analytical sensitivity and clinical performance of the commercially available influenza rapid tests in Taiwan. Four rapid tests for influenza virus (BinaxNow test, QuickVue test, TRU test, and Formosa Rapid test) were evaluated for their detection limit against four influenza viruses (the 2009 pandemic influenza A virus H1N1, seasonal influenza virus H1N1, H3N2, and influenza B virus) circulating in Taiwan. The viral load of these isolates were quantified by rtRT-PCR and then diluted 2-fold serially for the comparison. The lowest detectable viral load of the pandemic influenza A virus H1N1 by the Formosa Rapid test, QuickVue test, TRU test, and Binax Now test was 5.3 x 10(4), 1.0 x 10(5), 1.0 x 10(5), and 4.2 x 10(5) copies/mu l, respectively. Of these four tests, the two most sensitive tests (the QuickVue test and the Formosa Rapid test) were chosen to evaluate 62 nasopharyngeal specimens from patients who were suspected of infection with pandemic influenza A virus H1N1. The positive rate for the Formosa Rapid test and the QuickVue test were 53.2% (33/62) and 45.2% (28/62) (McNemar's test, P = 0.125), respectively. In conclusion, the Formosa Rapid test was the most sensitive test in the present study for the detection of influenza antigens and its clinical performance was similar to that of the QuickVue test (Kappa = 0.776). This suggests that the Formosa Rapid test could be used to aid clinical decision making in primary health care settings during outbreaks of influenza. (C) 2011 Elsevier B.V. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectInfluenza A virus H1N1en_US
dc.subjectPandemicen_US
dc.subjectRapid influenza diagnostic testen_US
dc.titlePerformance of rapid-test kits for the detection of the pandemic influenza A/H1N1 virusen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jviromet.2011.02.009en_US
dc.identifier.journalJOURNAL OF VIROLOGICAL METHODSen_US
dc.citation.volume173en_US
dc.citation.issue2en_US
dc.citation.spage387en_US
dc.citation.epage389en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000290836400034-
dc.citation.woscount6-
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