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dc.contributor.authorWu, Tung-Kungen_US
dc.contributor.authorChang, Cheng-Hsiangen_US
dc.contributor.authorLiu, Yuan-Tingen_US
dc.contributor.authorWang, Tsai-Tingen_US
dc.date.accessioned2014-12-08T15:12:43Z-
dc.date.available2014-12-08T15:12:43Z-
dc.date.issued2008en_US
dc.identifier.issn1527-8999en_US
dc.identifier.urihttp://hdl.handle.net/11536/9787-
dc.identifier.urihttp://dx.doi.org/10.1002/tcr.20157en_US
dc.description.abstractThe oxidosqualene cyclases (EC 5.4.99-) constitute a family of enzymes that catalyze diverse cyclization/rearrangement reactions of (3S)-2,3-oxidosqualene into a distinct array of sterols and triterpenes. The relationship between the cyclization mechanism and the enzymatic structure is extremely complex and compelling. This review covers the historical achievements of biomimetic studies and current progress in structural biology, molecular genetics, and bioinformatics studies to elucidate the mechanistic and structure-function relationships of the Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase-catalyzed cyclization/rearrangement reaction. (C) 2008 The Japan Chemical journal Forum and Wiley Periodicals, Inc. Chem Rec 8: 302-325; 2008: Published online in Wiley, InterScience (www.interscience.wiley.com) DOI 10. 1002/tcr.20157en_US
dc.language.isoen_USen_US
dc.subjectoxidosqualene cyclaseen_US
dc.subjectbiomimeticen_US
dc.subjectsite-saturated mutagenesisen_US
dc.subjectmolecular evolutionen_US
dc.subjectprotein engineeringen_US
dc.subjectprotein plasticityen_US
dc.titleSaccharomyces cerevisiae Oxidosqualene-Lanosterol Cyclase: A Chemistry-Biology Interdisciplinary Study of the Protein's Structure-Function-Reaction Mechanism Relationshipsen_US
dc.typeReviewen_US
dc.identifier.doi10.1002/tcr.20157en_US
dc.identifier.journalCHEMICAL RECORDen_US
dc.citation.volume8en_US
dc.citation.issue5en_US
dc.citation.spage302en_US
dc.citation.epage325en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000261341800004-
dc.citation.woscount22-
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