Saccharomyces cerevisiae Oxidosqualene-Lanosterol Cyclase: A Chemistry-Biology Interdisciplinary Study of the Protein's Structure-Function-Reaction Mechanism Relationships

doi:10.1002/tcr.20157

完整後設資料紀錄

DC 欄位	值	語言
dc.contributor.author	Wu, Tung-Kung	en_US
dc.contributor.author	Chang, Cheng-Hsiang	en_US
dc.contributor.author	Liu, Yuan-Ting	en_US
dc.contributor.author	Wang, Tsai-Ting	en_US
dc.date.accessioned	2014-12-08T15:12:43Z	-
dc.date.available	2014-12-08T15:12:43Z	-
dc.date.issued	2008	en_US
dc.identifier.issn	1527-8999	en_US
dc.identifier.uri	http://hdl.handle.net/11536/9787	-
dc.identifier.uri	http://dx.doi.org/10.1002/tcr.20157	en_US
dc.description.abstract	The oxidosqualene cyclases (EC 5.4.99-) constitute a family of enzymes that catalyze diverse cyclization/rearrangement reactions of (3S)-2,3-oxidosqualene into a distinct array of sterols and triterpenes. The relationship between the cyclization mechanism and the enzymatic structure is extremely complex and compelling. This review covers the historical achievements of biomimetic studies and current progress in structural biology, molecular genetics, and bioinformatics studies to elucidate the mechanistic and structure-function relationships of the Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase-catalyzed cyclization/rearrangement reaction. (C) 2008 The Japan Chemical journal Forum and Wiley Periodicals, Inc. Chem Rec 8: 302-325; 2008: Published online in Wiley, InterScience (www.interscience.wiley.com) DOI 10. 1002/tcr.20157	en_US
dc.language.iso	en_US	en_US
dc.subject	oxidosqualene cyclase	en_US
dc.subject	biomimetic	en_US
dc.subject	site-saturated mutagenesis	en_US
dc.subject	molecular evolution	en_US
dc.subject	protein engineering	en_US
dc.subject	protein plasticity	en_US
dc.title	Saccharomyces cerevisiae Oxidosqualene-Lanosterol Cyclase: A Chemistry-Biology Interdisciplinary Study of the Protein's Structure-Function-Reaction Mechanism Relationships	en_US
dc.type	Review	en_US
dc.identifier.doi	10.1002/tcr.20157	en_US
dc.identifier.journal	CHEMICAL RECORD	en_US
dc.citation.volume	8	en_US
dc.citation.issue	5	en_US
dc.citation.spage	302	en_US
dc.citation.epage	325	en_US
dc.contributor.department	生物科技學系	zh_TW
dc.contributor.department	Department of Biological Science and Technology	en_US
dc.identifier.wosnumber	WOS:000261341800004	-
dc.citation.woscount	22	-
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