標題: Magnetic-sensitive silica nanospheres for controlled drug release
作者: Hu, Shang-Hsiu
Liu, Ting-Yu
Huang, Hsin-Yang
Liu, Dean-Mo
Chen, San-Yuan
材料科學與工程學系
Department of Materials Science and Engineering
公開日期: 1-一月-2008
摘要: Recently, magnetic silica-based nanospheres have received great attention and displayed magnificent potential for bioimaging and therapeutic purposes. This study provided a way to accelerate drug release from magnetic-sensitive silica nanospheres by controlled bursting to a therapeutically effective concentration by a high-frequency magnetic field (HFMF). The magnetic-sensitive silica nanospheres were synthesized by an in situ process, with particle sizes about 50 nm and able to release specific amounts of drug in a burst manner via short exposure to a HFMF. The HFMF accelerates the rotation of magnetic nanoparticles deposited in the silica matrix with generated heat energy and subsequently enlarges the nanostructure of the silica matrix to produce porous channels that cause the drug to be released easily. By taking these magnetic-responsive controllable drug release behaviors, the magnetic silica nanospheres can be designed for controlled burst release of therapeutic agents for especially urgent physiological needs.
URI: http://dx.doi.org/10.1021/la701570z
http://hdl.handle.net/11536/9868
ISSN: 0743-7463
DOI: 10.1021/la701570z
期刊: LANGMUIR
Volume: 24
Issue: 1
起始頁: 239
結束頁: 244
顯示於類別:期刊論文


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