智慧型仿生系統之晶片系統平台技術開發---總計畫(I)

Abstract

智慧型仿生系統平台技術是所有生醫電子元件的基礎，若能將平台技術建立並通過嚴謹的生醫認證，將可大幅縮短一般生醫元件開發的時程，加速產業發展。因此在本計畫當中，除了要發展平台技術的電子元件，完成單晶片整合與微小化設計，並搭配無線傳輸技術，還規劃了生醫認證技術的開發，選定癲癇與憂鬱症兩種動物模型，將開發完成的單晶片系統實際植入動物體內，以驗證其功能性、可行性與安全性。本平台技術是以電極或感測器將生物訊號「讀入」經過前級放大器，再由放大器與濾波器提供可調式增益與可調式頻寬並經類比數位轉換器轉換為數位信號，將讀入訊號調整至最佳化狀態；接著讀出的生物訊號將送至生物訊號處理器(BSP)進行分析，生物訊號處理器(BSP)會利用生物訊號處理演算偵測癲癇症或憂鬱症的發生。若要抑制患者的異常症狀，還需要「寫入」的過程，將合適的抑制訊號送至數位類比轉換器處理後推動驅動器，驅動器再推動電極對生物組織產生抑制作用。最後整個系統可以微小化完全植入生物體內，只需要藉射頻傳送接收器將生理訊號傳送至體外監測，或將程式化參數送入體內控制系統即可。

An intelligent biomimetic system platform and its essential platform technologies can be applied to all kinds of biomedical devices. The establishment of this platform and the development of the strictly biomedicine-proven platform technologies will greatly help to shorten the time on developing a biomedical device and accelerate the industrial evolution. This project not only develops electronic devices in platform technology, highly integrated SOC and miniaturized system along with wireless transmission, it also maps out biomedical verification technology’s development to verify the SOC’s efficientcy, feasibility, and safety through implanting it into test animals with epilepsy or depression. This platform technology uses electrode or sensor to make the biological signals “read” through the pre-amplifier. The amplifier and filter can provide adjustable gain and adjustable bandwidth to adjust the signals to its best amplitude. The biological signals can then be passed to the biological signal processor(BSP) for analysis. The biological signal processing calculation is used to detect the occurring of epilepsy and depression. In order to inhibit the patients abnormal symptom, it would require a “writing” process. BSP generates suitable inhibiting signal for symptom inhibition. Then through the processing of digital-to-analog converter, the driver would be triggered to inhibit the biological tissues via the electrodes. Eventually, the whole system can be miniaturized to be fully implanted into the body, and through RF transceiver, biological signals can be transmitted outside the body for observation, or the parameter controlling the implanted system be sent into the body.