標題: Using skin sympathetic nerve activity to estimate stellate ganglion nerve activity in dogs
作者: Jiang, Zhaolei
Zhao, Ye
Doytchinova, Anisiia
Kamp, Nicholas J.
Tsai, Wei-Chung
Yuan, Yuan
Adams, David
Wagner, David
Shen, Changyu
Chen, Lan S.
Everett, Thomas H.
Lin, Shien-Fong
Chen, Peng-Sheng
分子醫學與生物工程研究所
Institute of Molecular Medicine and Bioengineering
關鍵字: Autonomic nervous system;Sympathetic nerve;Stellate ganglion;Cardiac arrhythmia
公開日期: 1-Jun-2015
摘要: BACKGROUND Stellate ganglion nerve activity (SGNA) is important in cardiac arrhythmogenesis. However, direct recording of SGNA requires access to the thoracic cavity. Skin of upper thorax is innervated by sympathetic nerve fibers originating from the stellate ganglia and is easily accessible. OBJECTIVE The purpose of this study was to test the hypothesis that thoracic skin nerve activity (SKNA) can be used to estimate SGNA. METHODS We recorded SGNA and SKNAs using surface electrocardiogram leads in 5 anesthetized and 4 ambulatory dogs. Apamin injected into the right stellate ganglion abruptly increased both right SGNA and SKNA in 5 anesthetized dogs. We integrated nerve activities and averaged heart rate in each 1-minure window over 10 minutes, We implanted a radiotransmitter to record Left SGNA in 4 ambulatory dogs (2 normal, 1 with myocardial infarction, 1 with intermittent rapid atrial pacing). After 2 weeks of recovery, we simultaneously recorded the SKNA and Left SGNA continuously for 30 minutes when the dogs were ambulatory. RESULTS There was a positive correlation [average r = 0.877, 95% confidence interval (CI) 0.732-1.000, P<.05 for each dog] between integrated skin nerve activity (iSKNA) and SGNA (iSGNA) and between iSKNA and heart rate (average r = 0.837, 95% CI 0.752-0.923, P<.05). Similar to that found in the anesthetized dogs, there was a positive correlation (average r = 0.746, 95% CI 0.527-0.964, P<.05) between iSKNA and iSGNA and between iSKNA and heart rate (average r = 0.706, 95% CI 0.484-0.927, P<.05). CONCLUSION SKNAs can be used to estimate SGNA in dogs.
URI: http://hdl.handle.net/11536/124792
ISSN: 1547-5271
期刊: HEART RHYTHM
Volume: 12
起始頁: 1324
結束頁: 1332
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