標題: The distribution and drug susceptibilities of clinical Candida species in TSARY 2014
作者: Zhou, Zi-Li
Lin, Chih-Chao
Chu, Wen-Li
Yang, Yun-Liang
Lo, Hsiu-Jung
生物科技學系
分子醫學與生物工程研究所
Department of Biological Science and Technology
Institute of Molecular Medicine and Bioengineering
關鍵字: Antifungal;Candida species;Drug susceptibility
公開日期: 十二月-2016
摘要: The species distribution and drug susceptibilities of 1106 Candida isolates collected in Taiwan Surveillance of Antimicrobial Resistance of Yeasts (TSARY) in 2014 were determined. Candida albicans is still the dominant species, accounting for 35.9%, followed by 28.3% C. glabrata, 26.6% C. tropicalis, 5.2% C. parapsilosis, 1.0% C. krusei, and 3.0% of 13 other species. Interestingly, the prevalence of candidemia caused by C. glabrata in the present study is significantly higher than that in previous three surveys (39/220 vs. 54/471, P = 0.025). We found that 31 (2.8%), 24 (2.2%), 1 (0.09%), and 0 isolates were resistant to fluconazole, voriconazole, anidulafungin, and amphotericin B, respectively. There is a significant increase in fluconazole (P = 0.00002) and voriconazole (P = 0.00006) resistant rates when compared to the isolates collected in 2010. Importantly, all the 24 voriconazole resistant isolates identified were also resistant to fluconazole. Hence, cross-resistance among azole-type drugs is an emerging issue for managing fungal infections. (C) 2016 Published by Elsevier Inc.
URI: http://dx.doi.org/10.1016/j.diagmicrobio.2016.09.009
http://hdl.handle.net/11536/132781
ISSN: 0732-8893
DOI: 10.1016/j.diagmicrobio.2016.09.009
期刊: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Volume: 86
Issue: 4
起始頁: 399
結束頁: 404
顯示於類別:期刊論文