標題: | Newly reduced graphene oxide/gold oxide neural-chemical interface on multi-channel neural probes to enhance the electrochemical properties for biosensors |
作者: | Liu, Ta-Chung Chu, Chao-Yi Chen, You-Yin Chen, San-Yuan 材料科學與工程學系 Department of Materials Science and Engineering |
公開日期: | 1-一月-2016 |
摘要: | In this study, a facile one-step Cyclic Voltammetry (CV) electrophoresis was proposed for designing a reduced graphene oxide/gold oxide (rGO/AuOx) modified electrode by using chloride ions (Cl-) with the simultaneous occurrence of gold oxidation and GO reduction to induce the intimate attachment of negatively charged rGO sheets on the positively charged Au+/Au3+ clusters by electrostatic interaction. The surface microstructure and the oxygen functional groups of rGO/AuOx can be tuned by controlling the dissolution rate of gold via the deposition scan rate. At a low deposition scan rate, the rGO/AuOx electrode with well-dispersive rGO sheets and large active sites can induce rapid electron transfer to promote H2O2 detection. The amperometric response results displayed a relative fast response of less than 5 s with a low detection limit of 0.63 mu M (S/N = 3). Also, the rGO/AuOx neural-chemical interface can be modified at the multi-channels on neural probe and they exhibited excellent sensing performance to H2O2. The results demonstrated that the rGO/AuOx modified electrode integrated with a neural probe using this one-step electrochemical deposition can provide a faster response and higher sensitivity by optimizing and controlling the surface microstructures of rGO/AuOx, which would serve as a platform for medical application such as biosensors for multi-sensing. |
URI: | http://dx.doi.org/10.1039/c6ra01016d http://hdl.handle.net/11536/133572 |
ISSN: | 2046-2069 |
DOI: | 10.1039/c6ra01016d |
期刊: | RSC ADVANCES |
Volume: | 6 |
Issue: | 33 |
起始頁: | 27614 |
結束頁: | 27622 |
顯示於類別: | 期刊論文 |