標題: | Functional Supramolecular Polymers: A Fluorescent Microfibrous Network in a Supramolecular Hydrogel for High-Contrast Live Cell-Material Imaging in 3D Environments |
作者: | Hsu, Shu-Min Wu, Fang-Yi Cheng, Hsun Huang, Yu-Tang Hsieh, Yi-Ru Tseng, Dion Tzu-Huan Yeh, Mei-Yu Hung, Shih-Chieh Lin, Hsin-Chieh 材料科學與工程學系 Department of Materials Science and Engineering |
公開日期: | 21-Sep-2016 |
摘要: | A new bottom-up strategy based on aromatic peptide amphiphile is developed for a high-contrast visualization of 3D live cell-material imaging-something that has been difficult to achieve previously because of the problems associated with the diffraction of light by the nanosized peptide materials and the aggregation-caused quenching of aggregated pi-conjugated fluorophores in the nanostructures. This study reports an example of a novel supramolecular hydrogelator, naphthaleneimide-phenylalanine (NI-Phe), which forms a self-supporting hydrogel displaying a unique microfibrous network and promising aggregation-induced emission characteristics at pH 7.4. The storage modulus of the NI-Phe gel supports the mass of a cell for 3D cell culturing. This work illustrates a new dopant-free supramolecular approach, complementary to well-established doping procedures that should facilitate the development of live cell imaging in 3D scaffolding materials. |
URI: | http://dx.doi.org/10.1002/adhm.201600342 http://hdl.handle.net/11536/134226 |
ISSN: | 2192-2640 |
DOI: | 10.1002/adhm.201600342 |
期刊: | ADVANCED HEALTHCARE MATERIALS |
Volume: | 5 |
Issue: | 18 |
起始頁: | 2406 |
結束頁: | 2412 |
Appears in Collections: | Articles |