標題: | Preparation and supramolecular self-assembly of a polypeptide-block-polypseudorotaxane |
作者: | Lee, HF Sheu, HS Jeng, US Huang, CF Chang, FC 應用化學系 Department of Applied Chemistry |
公開日期: | 26-Jul-2005 |
摘要: | We have successfully prepared a new class of self-assembled biomaterial: a polypeptide-block-polypseudorotaxane diblock copolymer. This diblock copolymer is comprised of an a-helical polypeptide rod, based on gamma-benzyl-L-glutamate, and an originally coiled segment P(EO19-r-PO3); it forms inclusion complexes with a-cyclodextrins (alpha-CDs) to give crystalline polypseudorotaxanes. Formation of the polypseudorotaxane converts the conformation of P(EO19-r-PO3) from a flexible chain into a rodlike structure, which results in a novel block copolymer exhibiting a rod-rod conformation. Intrinsic interactions (e.g., the polypseudorotaxane's channel-type crystallization, the polypeptide's secondary structure, and microphase separation) within and between these rod-rod diblock copolymers contribute to their hierarchical self-assembly behavior, which we characterized using DSC, H-1 NMR spectroscopy, C-13 CP/MAS NMR spectroscopy, WAXS, and SAXS. The data obtained from the WAXS and SAXS studies clearly indicate the formation of juxtaposed bilayer-like nanostructure featuring hexagonally packed PBLG stacks and channel-type polypseudorotaxane moieties. |
URI: | http://dx.doi.org/10.1021/ma050254a http://hdl.handle.net/11536/13471 |
ISSN: | 0024-9297 |
DOI: | 10.1021/ma050254a |
期刊: | MACROMOLECULES |
Volume: | 38 |
Issue: | 15 |
起始頁: | 6551 |
結束頁: | 6558 |
Appears in Collections: | Articles |
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