標題: Magnesium oxide use and reduced risk of dementia: a retrospective, nationwide cohort study in Taiwan
作者: Tzeng, Nian-Sheng
Chung, Chi-Hsiang
Lin, Fu-Huang
Huang, Ching-Feng
Yeh, Chin-Bin
Huang, San-Yuan
Lu, Ru-Band
Chang, Hsin-An
Kao, Yu-Chen
Yeh, Hui-Wen
Chiang, Wei-Shan
Chou, Yu-Ching
Tsao, Chang-Huei
Wu, Yung-Fu
Chien, Wu-Chien
生物資訊及系統生物研究所
Institude of Bioinformatics and Systems Biology
關鍵字: Dementia;magnesium oxide;cohort study;propensity score;risk factors;dataset
公開日期: 1-Jan-2018
摘要: Objective: Dietary magnesium may be associated with a lower risk of dementia; however, the impact of magnesium oxide (MgO), a common laxative, on dementia has yet to be elucidated. This study aimed to investigate the association between the usage of MgO and the risk of developing dementia. Methods: We used a dataset from the National Health Research Institute Database (NHRID) of Taiwan containing one million randomly sampled subjects to identify patients aged >= 50 years with no history of MgO usage. A total of 1547 patients who had used MgO were enrolled, along with 4641 controls who had not used the MgO propensity score matched by age, gender and comorbidity, at a ratio of 1:3. After adjusting for confounding risk factors, a Cox proportional hazards model was used to compare the risk of developing dementia during a 10 year follow-up period. Results: Of the enrolled patients, 44 (2.84%) developed dementia, when compared to 199 (4.28%) in the control group. The Cox proportional hazards regression analysis revealed that the patients who had used MgO were less likely to develop dementia with a crude hazard ratio of 0.617 (95% CI, 0.445-0.856, p=.004). After adjusting for age, gender, comorbidity, geographical area and urbanization level of residence, and monthly income, the adjusted hazard ratio was 0.517 (95% CI, 0.412-0.793, p=.001). Conclusions: The patients who used MgO had a decreased risk of developing dementia. Further studies on the effects of MgO in reducing the risk of dementia are therefore warranted.
URI: http://dx.doi.org/10.1080/03007995.2017.1385449
http://hdl.handle.net/11536/144761
ISSN: 0300-7995
DOI: 10.1080/03007995.2017.1385449
期刊: CURRENT MEDICAL RESEARCH AND OPINION
Volume: 34
起始頁: 163
結束頁: 169
Appears in Collections:Articles