標題: Fe Doped Magnetic Nanodiamonds Made by Ion Implantation as Contrast Agent for MRI
作者: Lin, Bo-Rong
Chen, Chien-Hsu
Kunuku, Srinivasu
Chen, Tzung-Yuang
Hsiao, Tung-Yuan
Niu, Huan
Lee, Chien-Ping
電子工程學系及電子研究所
Department of Electronics Engineering and Institute of Electronics
公開日期: 4-May-2018
摘要: We report in this paper a new MRI contrast agent based on magnetic nanodiamonds fabricated by Fe ion implantation. The Fe atoms that are implanted into the nanodiamonds are not in direct contact with the outside world, enabling this new contrast agent to be free from cell toxicity. The image enhancement was shown clearly through T2 weighted images. The concentration dependence of the T2 relaxation time gives a relaxivity value that is about seven times that of the regular non-magnetic nanodiamonds. Cell viability study has also been performed. It was shown that they were nearly free from cytotoxicity independent of the particle concentration used. The imaging capability demonstrated here adds a new dimension to the medical application of nanodiamonds. In the future one will be able to combine this capability of magnetic nanodiamonds with other functions through surface modifications to perform drug delivery, targeted therapy, localized thermal treatment and diagnostic imaging at the same time.
URI: http://dx.doi.org/10.1038/s41598-018-25380-1
http://hdl.handle.net/11536/144936
ISSN: 2045-2322
DOI: 10.1038/s41598-018-25380-1
期刊: SCIENTIFIC REPORTS
Volume: 8
Appears in Collections:Articles