Rapid Two-Step Synthesis of Benzimidazo[1 ',2 ':1,5]-pyrrolo[2,3-c]isoquinolines by a Three-Component Coupling Reaction

doi:10.1021/co500049r

完整後設資料紀錄

DC 欄位	值	語言
dc.contributor.author	Narhe, Bharat D.	en_US
dc.contributor.author	Tsai, Min-Huan	en_US
dc.contributor.author	Sun, Chung-Ming	en_US
dc.date.accessioned	2019-04-02T06:00:06Z	-
dc.date.available	2019-04-02T06:00:06Z	-
dc.date.issued	2014-08-01	en_US
dc.identifier.issn	2156-8952	en_US
dc.identifier.uri	http://dx.doi.org/10.1021/co500049r	en_US
dc.identifier.uri	http://hdl.handle.net/11536/147783	-
dc.description.abstract	A two-step, three-component coupling reaction on ionic liquid supported 2-cyanomethylbenzimidazoles, methyl 2-formylbenzoate, and isocyanides under microwave activation is explored. Knoevenagel condensation of 2-cyanomethylbenzimidazole with methyl-2-formylbenzoate in the presence of piperidine catalyst is followed by [4 + 1] cycloaddition with an isocyanide in the next step. Consequent intramolecular delta-lactam formation allows rapid construction of novel aza-pentacycles, benzimidazo [1',2':1,5]pyrrolo [2,3-c]isoquinolines.	en_US
dc.language.iso	en_US	en_US
dc.subject	microwave	en_US
dc.subject	ionic liquid support	en_US
dc.subject	pyrrolo[1,2-a]benzimidazole	en_US
dc.subject	benzimidazo[1',2':1,5]pyrrolo[2,3-c]isoquinolines	en_US
dc.title	Rapid Two-Step Synthesis of Benzimidazo[1 ',2 ':1,5]-pyrrolo[2,3-c]isoquinolines by a Three-Component Coupling Reaction	en_US
dc.type	Article	en_US
dc.identifier.doi	10.1021/co500049r	en_US
dc.identifier.journal	ACS COMBINATORIAL SCIENCE	en_US
dc.citation.volume	16	en_US
dc.citation.spage	421	en_US
dc.citation.epage	427	en_US
dc.contributor.department	應用化學系	zh_TW
dc.contributor.department	Department of Applied Chemistry	en_US
dc.identifier.wosnumber	WOS:000340344500008	en_US
dc.citation.woscount	10	en_US
顯示於類別：	期刊論文