標題: | RECONSTITUTED APOLIPOPROTEIN B LIPOPARTICLE, A PREPARATION METHOD AND USES THEREOF |
作者: | Chia-Ching Chang Gong-Shen Chen Tsai-Mu Cheng Hsueh-Liang Chu |
公開日期: | 27-Jul-2017 |
摘要: | The present invention provides a method for preparing a reconstituted apolipoprotein B lipoparticle and the method comprises steps of (a) dissolving an apolipoprotein B and a lipid in a first buffer containing 2 M to 8 M urea and 1 wt % to 15 wt % amphiphilic compounds to form a mixture; and (b) dialyzing the mixture against a second buffer containing 0 M to 2M urea and 0 wt % to 0.5 wt % amphiphilic compounds for 1 to several times for lowering concentrations of the urea and the amphiphilic compounds in the mixture. The present invention further provides an apolipoprotein B lipoparticle and a use for the production of an apolipoprotein B lipoparticle used for delivering a hydrophobic substance. |
官方說明文件#: | A61K009/51 A61K031/09 A61K049/18 |
URI: | http://hdl.handle.net/11536/151292 |
專利國: | USA |
專利號碼: | 20170209388 |
Appears in Collections: | Patents |
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