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dc.contributor.authorChu, Szu-Yingen_US
dc.contributor.authorChu, Chih-Hungen_US
dc.contributor.authorHsien-DaHuangen_US
dc.contributor.authorYen, Meng-Huaen_US
dc.contributor.authorHong, Hsiao-Chinen_US
dc.contributor.authorChao, Po-Hanen_US
dc.contributor.authorWang, Yu-Hsuanen_US
dc.contributor.authorChen, Po-Yuen_US
dc.contributor.authorNian, Shi-Xinen_US
dc.contributor.authorChen, Yu-Ruen_US
dc.contributor.authorLiou, Li-Yingen_US
dc.contributor.authorLiu, Yu-Chenen_US
dc.contributor.authorChen, Hui-Meien_US
dc.contributor.authorLin, Feng-Maoen_US
dc.contributor.authorChang, Yun-Tingen_US
dc.contributor.authorChen, Chih-Chiangen_US
dc.contributor.authorLee, Oscar K.en_US
dc.date.accessioned2019-05-02T00:25:57Z-
dc.date.available2019-05-02T00:25:57Z-
dc.date.issued2019-04-03en_US
dc.identifier.issn2041-1723en_US
dc.identifier.urihttp://dx.doi.org/10.1038/s41467-019-09402-8en_US
dc.identifier.urihttp://hdl.handle.net/11536/151666-
dc.description.abstractTissues and cells in organism are continuously exposed to complex mechanical cues from the environment. Mechanical stimulations affect cell proliferation, differentiation, and migration, as well as determining tissue homeostasis and repair. By using a specially designed skinstretching device, we discover that hair stem cells proliferate in response to stretch and hair regeneration occurs only when applying proper strain for an appropriate duration. A counterbalance between WNT and BMP-2 and the subsequent two-step mechanism are identified through molecular and genetic analyses. Macrophages are first recruited by chemokines produced by stretch and polarized to M2 phenotype. Growth factors such as HGF and IGF-1, released by M2 macrophages, then activate stem cells and facilitate hair regeneration. A hierarchical control system is revealed, from mechanical and chemical signals to cell behaviors and tissue responses, elucidating avenues of regenerative medicine and disease control by demonstrating the potential to manipulate cellular processes through simple mechanical stimulation.en_US
dc.language.isoen_USen_US
dc.titleMechanical stretch induces hair regeneration through the alternative activation of macrophagesen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41467-019-09402-8en_US
dc.identifier.journalNATURE COMMUNICATIONSen_US
dc.citation.volume10en_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department交大名義發表zh_TW
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.departmentNational Chiao Tung Universityen_US
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.identifier.wosnumberWOS:000463171300013en_US
dc.citation.woscount0en_US
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