標題: Elevated interleukin-4 levels predicted advanced fibrosis in chronic hepatitis C
作者: Batsaikhan, Batbold
Lu, Ming-Ying
Yeh, Ming-Lun
Huang, Ching-, I
Huang, Chung-Feng
Lin, Zu-Yau
Chen, Shinn-Cherng
Huang, Jee-Fu
Hsieh, Ping-Hsin
Chuang, Wan-Long
Lee, Jin-Ching
Yu, Ming-Lung
Dai, Chia-Yen
生醫工程研究所
Institute of Biomedical Engineering
關鍵字: Cytokines;HCV;Interleukin 4;Liver fibrosis;Liver fibrosis indexes
公開日期: 1-Apr-2019
摘要: Background: Cytokine imbalance has been associated with chronic hepatitis C virus (HCV) infection. We hypothesized that cytokines have an important role in fibrosis development in HCV infection. Methods: Data of 92 patients were analyzed retrospectively. Fluorescent Bead immunoassay was used to measure the following serum cytokine levels: Interferon , tumor necrosis factor , interleukin (IL)-1, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, and IL-12. Various statistical analyses were used as appropriate. Results: Of the 92 HCV-infected patients, 49 (53.3%) were male, 23 (25%) patients had advanced (fibrosis grades 3-4) fibrosis, and the mean age of the study population was 51.9 9.4 years. Elevation of baseline IL-4 level (>490 pg/mL) was associated with liver fibrosis grade by (2) test (odds ratio [OR] = 2.99; 95%, CI = 1.02-8.78; p = 0.042) and multivariate logistic regression (OR = 4.26; 95% CI = 1.13-16.02; p = 0.032). Also, IL-4 had strong diagnostic value in advanced liver fibrosis by using area under receiver operating characteristics curve analysis. Assessment of fibrosis score was consequently developed from our findings and compared with other noninvasive serum markers to assess liver fibrosis. Conclusion: This study provides evidence that increased IL-4 expression predicted advanced liver fibrosis in treatment of naive HCV-infected patients. The newly developed FIL4 score had good predictive value for advanced fibrosis before treatment and this value was even strong in HCV-genotype 1b patients.
URI: http://dx.doi.org/10.1097/JCMA.0000000000000064
http://hdl.handle.net/11536/152402
ISSN: 1726-4901
DOI: 10.1097/JCMA.0000000000000064
期刊: JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
Volume: 82
Issue: 4
起始頁: 277
結束頁: 281
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