標題: Iron embedded magnetic nanodiamonds for in vivo MRI contrast enhancement
作者: Lin, Bo-Rong
Chen, Chien-Hsu
Chang, Chun-Hsiang
Kunuku, Srinivasu
Chen, Tzung-Yuang
Hsiao, Tung-Yuan
Yu, Hung-Kai
Chang, Yu-Jen
Liao, Li-Chuan
Chen, Fang-Hsin
Niu, Huan
Lee, Chien-Ping
電子工程學系及電子研究所
Department of Electronics Engineering and Institute of Electronics
關鍵字: iron;nanodiamonds;ion implantation;in vivo;mri;contrast enhancement
公開日期: 11-Dec-2019
摘要: Although nanodiamonds have long being considered as a potential tool for biomedical research, the practical in vivo magnetic resonance imaging (MRI) application of nanodiamonds remains relatively unexplored. In this paper, we present the first application of in vivo MRI contrast enhancement using only iron embedded magnetic nanodiamonds. An MR image enhancement was clearly demonstrated in the rendering of T2-weighted images of mice obtained using an unmodified commercial MRI scanner. The excellent contrast obtained using these nanodiamonds opens the door to the non-invasive in vivo tracking of nanodiamonds and image enhancement. In the future, one can apply these magnetic nanodiamonds together with surface modifications to facilitate drug delivery, targeted therapy, localized thermal treatment, and diagnostic imaging.
URI: http://dx.doi.org/10.1088/1361-6463/ab41e8
http://hdl.handle.net/11536/153082
ISSN: 0022-3727
DOI: 10.1088/1361-6463/ab41e8
期刊: JOURNAL OF PHYSICS D-APPLIED PHYSICS
Volume: 52
Issue: 50
起始頁: 0
結束頁: 0
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