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dc.contributor.authorQian, Xin-Hongen_US
dc.contributor.authorWu, Yi-Chungen_US
dc.contributor.authorYang, Tzu-Yien_US
dc.contributor.authorCheng, Cheng-Hsiangen_US
dc.contributor.authorChu, Hsing-Chienen_US
dc.contributor.authorCheng, Wan-Hsuehen_US
dc.contributor.authorYen, Ting-Yangen_US
dc.contributor.authorLin, Tzu-Hanen_US
dc.contributor.authorLin, Yung-Jenen_US
dc.contributor.authorLee, Yu-Chien_US
dc.contributor.authorChang, Jia-Hengen_US
dc.contributor.authorLin, Shih-Tingen_US
dc.contributor.authorLi, Shang-Hsuanen_US
dc.contributor.authorWu, Tsung-Chenen_US
dc.contributor.authorHuang, Chien-Changen_US
dc.contributor.authorWang, Sung-Haoen_US
dc.contributor.authorLee, Chia-Foneen_US
dc.contributor.authorYang, Chia-Hsiangen_US
dc.contributor.authorHung, Chung-Chihen_US
dc.contributor.authorChi, Tai-Shihen_US
dc.contributor.authorLiu, Chien-Haoen_US
dc.contributor.authorKer, Ming-Douen_US
dc.contributor.authorWu, Chung-Yuen_US
dc.date.accessioned2020-01-02T00:04:19Z-
dc.date.available2020-01-02T00:04:19Z-
dc.date.issued2019-11-01en_US
dc.identifier.issn0018-9294en_US
dc.identifier.urihttp://dx.doi.org/10.1109/TBME.2019.2901374en_US
dc.identifier.urihttp://hdl.handle.net/11536/153365-
dc.description.abstractObjective: To develop and verify a CMOS bone-guided cochlear implant (BGCI) microsystem with electrodes placed on the bone surface of the cochlea and the outside of round window for treating high-frequency hearing loss. Methods: The BGCI microsystem consists of an external unit and an implanted unit. The external system-on-chip is designed to process acoustic signals through an acquisition circuit and an acoustic DSP processor to generate stimulation patterns and commands that are transmitted to the implanted unit through a 13.56 MHz wireless power and bidirectional data telemetry. In the wireless power telemetry, a voltage doubler/tripler (2X/3X) active rectifier is used to enhance the power conversion efficiency and generate 2 and 3 V output voltages. In the wireless data telemetry, phase-locked loop based binary phase-shift keying and load-shift keying modulators/demodulators are adopted for the downlink and uplink data through high-Q coils, respectively. The implanted chip with four-channel high-voltage-tolerant stimulator generates biphasic stimulation currents up to 800 mu A. Results: Electrical tests on the fabricated BGCI microsystem have been performed to verify the chip functions. The in vivo animal tests in guinea pigs have shown the evoked third wave of electrically evoked auditory brainstem response waveforms. It is verified that auditory nerves can be successfully stimulated and acoustic hearing can be partially preserved. Conclusion and Significance: Different from traditional cochlear implants, the proposed BGCI microsystem is less invasive, preserves partially acoustic hearing, and provides an effective alternative for treating high-frequency hearing loss.en_US
dc.language.isoen_USen_US
dc.subjectActive rectifieren_US
dc.subjectbone-guideden_US
dc.subjectcochlear implanten_US
dc.subjectinductive link power supplyen_US
dc.subjectimplantable medical devicesen_US
dc.titleDesign and In Vivo Verification of a CMOS Bone-Guided Cochlear Implant Microsystemen_US
dc.typeArticleen_US
dc.identifier.doi10.1109/TBME.2019.2901374en_US
dc.identifier.journalIEEE TRANSACTIONS ON BIOMEDICAL ENGINEERINGen_US
dc.citation.volume66en_US
dc.citation.issue11en_US
dc.citation.spage3156en_US
dc.citation.epage3167en_US
dc.contributor.department電子工程學系及電子研究所zh_TW
dc.contributor.department電機工程學系zh_TW
dc.contributor.departmentDepartment of Electronics Engineering and Institute of Electronicsen_US
dc.contributor.departmentDepartment of Electrical and Computer Engineeringen_US
dc.identifier.wosnumberWOS:000502102200017en_US
dc.citation.woscount0en_US
Appears in Collections:Articles