標題: Pregnenolonyl-alpha-glucoside exhibits marked anti-cancer and CYP17A1 enzymatic inhibitory activities
作者: Chou, Feng-Pai
Hsu, Wen-Chen
Huang, Sheng-Cih
Chang, Chin-Yuan
Chiou, Ya-Sheng
Tsai, Chia-Tse
Lyu, Jason WenJay
Chen, Wei-Ting
Wu, Tung-Kung
交大名義發表
生物科技學系
National Chiao Tung University
Department of Biological Science and Technology
公開日期: 7-Feb-2020
摘要: We report here that pregnenolonyl-alpha-glucoside (2), a steryl glycoside synthesized directly from pregnenolone and glucose via a consecutive multienzyme-catalyzed process, exhibits marked dose-dependent cytotoxic activity against HT29, AGS, and ES-2 cells with IC50 values of 23.5 to 50.9 mu M. An in vitro CYP17A1 binding pattern assay and protein-ligand docking model support that 2, like abiraterone, binds in the active site heme iron pocket of CYP17A1.
URI: http://dx.doi.org/10.1039/c9cc09415f
http://hdl.handle.net/11536/153728
ISSN: 1359-7345
DOI: 10.1039/c9cc09415f
期刊: CHEMICAL COMMUNICATIONS
Volume: 56
Issue: 11
起始頁: 1733
結束頁: 1736
Appears in Collections:Articles