標題: Label-Free Optical Microscope Based on a Phase-Modulated Femtosecond Pump-Probe Approach with Subdiffraction Resolution
作者: Fathi, Amir
Chung, Chao-Yu
Lee, Yuan-Pern
Diau, Eric Wei-Guang
交大名義發表
應用化學系
應用化學系分子科學碩博班
National Chiao Tung University
Department of Applied Chemistry
Institute of Molecular science
關鍵字: laser scanning microscope;optical microscopy;pump-probe imaging;super-resolution;ultrafast microscopy
公開日期: 18-Mar-2020
摘要: A far-field optical microscope (OM) is a powerful noninvasive, nondestructive tool to study sub-micrometer structures and organisms, which has been used for decades to study the interactions between light and matter in the spatial domain. We report here a sophisticated label-free OM method with superspatial resolution to visualize ZnO nanoparticles. Of three femtosecond pulses, two served as pumps at 1000 nm and the other one served as a probe at 774 nm. The two pumps (one of Gaussian shape and the other of toroidal shape) were generated with a phase difference of 180 degrees. When the conventional pump-probe approach was used in the absence of a second toroidal pump, a ZnO nanoparticle was observed to show a particle size of 445 nm because of the limit of diffraction. In contrast, when the second toroidal pump was applied out of phase, the obtained OM image showed a ZnO nanoparticle down to 96 nm. We demonstrated for the first time that the reported phase-modulated pump-probe approach has an ability for spatial resolution beyond its optical diffraction limit and a potential for label-free imaging applications in nanomaterials and life sciences.
URI: http://dx.doi.org/10.1021/acsphotonics.9b01821
http://hdl.handle.net/11536/154387
ISSN: 2330-4022
DOI: 10.1021/acsphotonics.9b01821
期刊: ACS PHOTONICS
Volume: 7
Issue: 3
起始頁: 607
結束頁: 613
Appears in Collections:Articles