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dc.contributor.authorYeh, Hui-Wenen_US
dc.contributor.authorChien, Wu-Chienen_US
dc.contributor.authorChung, Chi-Hsiangen_US
dc.contributor.authorChang, Hsin-Anen_US
dc.contributor.authorKao, Yu-Chenen_US
dc.contributor.authorTzeng, Nian-Shengen_US
dc.date.accessioned2020-10-05T02:01:58Z-
dc.date.available2020-10-05T02:01:58Z-
dc.date.issued1970-01-01en_US
dc.identifier.issn0276-3478en_US
dc.identifier.urihttp://dx.doi.org/10.1002/eat.23367en_US
dc.identifier.urihttp://hdl.handle.net/11536/155382-
dc.description.abstractBackground Previous studies have shown elevated cancer risk in anorexia nervosa but the literature on other eating disorders (EDs) is scarce. This study aimed to investigate the association between all EDs and esophageal, stomach, and other cancers. Methods We used a retrospective cohort design, based on a two-million randomized longitudinal health insurance dataset, a sub-dataset of Taiwan's National Health Insurance Research Database. From all the potential participants aged 20 years or more, a total of 6,628 participants were enrolled, including 1,657 patients with EDs, with sex-, age-, and indexed date-matched (1:3) 4,971 controls. Each participant was individually tracked from 2000 to 2015 to identify incident cases of cancers, including esophageal cancer (EC), stomach cancer (SC), and all other cancers (AOC). The multivariate Cox proportional hazards model was employed to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between EDs and cancer. Results Of the total 6,628 enrollees, 222 in 1,657 individuals with EDs and 810 in the 4,971 non-ED control individuals developed cancer (1,262.40 vs. 1,472.15 per 100,000 person-years), and the Kaplan-Meier survival analysis was not statistically significant (log-rank,p= .324). However, after adjusting for covariates, the risk of EC and SC among the individuals with an ED was significantly higher, with adjusted HRs of 5.32 (95% CI: 1.07-26.49,p < .001) and 4.61 (95% CI: 1.91-11.14,p < .001), respectively. EDs were not associated with other cancers. Conclusions This study provides evidence for the association between EDs and the risk for EC and SC. Further research on mechanisms and prevention is therefore needed.en_US
dc.language.isoen_USen_US
dc.subjecteating disordersen_US
dc.subjectesophageal canceren_US
dc.subjectNational Health Insurance Research Databaseen_US
dc.subjectstomach canceren_US
dc.titleEating disorders and the risk of esophageal and stomachcancers-Anationwide, population-based cohort study in Taiwanen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/eat.23367en_US
dc.identifier.journalINTERNATIONAL JOURNAL OF EATING DISORDERSen_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.identifier.wosnumberWOS:000568853100001en_US
dc.citation.woscount0en_US
Appears in Collections:Articles