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dc.contributor.authorYang, Yun-Liangen_US
dc.contributor.authorLin, Chih-Chaoen_US
dc.contributor.authorChang, Te-Pinen_US
dc.contributor.authorLauderdale, Tsai-Lingen_US
dc.contributor.authorChen, Hui-Tingen_US
dc.contributor.authorLee, Ching-Fuen_US
dc.contributor.authorHsieh, Chih-Wenen_US
dc.contributor.authorChen, Pei-Chenen_US
dc.contributor.authorLo, Hsiu-Jungen_US
dc.date.accessioned2014-12-08T15:23:16Z-
dc.date.available2014-12-08T15:23:16Z-
dc.date.issued2012-04-05en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://dx.doi.org/e34609en_US
dc.identifier.urihttp://hdl.handle.net/11536/16345-
dc.description.abstractInfections caused by treatment-resistant non-albicans Candida species, such as C. tropicalis, has increased, which is an emerging challenge in the management of fungal infections. Genetically related diploid sequence type (DST) strains of C. tropicalis exhibiting reduced susceptibility to fluconazole circulated widely in Taiwan. To identify the potential source of these wildly distributed DST strains, we investigated the possibility of the presence in soil of such C. tropicalis strains by pulsed field gel electrophoresis (PFGE) and DST typing methods. A total of 56 C. tropicalis isolates were recovered from 26 out of 477 soil samples. Among the 18 isolates with reduced susceptibility to fluconazole, 9 belonged to DST149 and 3 belonged to DST140. Both DSTs have been recovered from our previous studies on clinical isolates from the Taiwan Surveillance of Antimicrobial Resistance of Yeasts (TSARY) program. Furthermore, these isolates were more resistant to agricultural azoles. We have found genetically related C. tropicalis exhibiting reduced susceptibility to fluconazole from the human hosts and environmental samples. Therefore, to prevent patients from acquiring C. tropicalis with reduced susceptibility to azoles, prudent use of azoles in both clinical and agricultural settings is advocated.en_US
dc.language.isoen_USen_US
dc.titleComparison of Human and Soil Candida tropicalis Isolates with Reduced Susceptibility to Fluconazoleen_US
dc.typeArticleen_US
dc.identifier.doie34609en_US
dc.identifier.journalPLOS ONEen_US
dc.citation.volume7en_US
dc.citation.issue4en_US
dc.citation.epageen_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department分子醫學與生物工程研究所zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitute of Molecular Medicine and Bioengineeringen_US
dc.identifier.wosnumberWOS:000305010500020-
dc.citation.woscount8-
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