完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Tsai, Min-Yeh | en_US |
dc.contributor.author | Yuan, Jian-Min | en_US |
dc.contributor.author | Teranishi, Yoshiaki | en_US |
dc.contributor.author | Lin, Sheng Hsien | en_US |
dc.date.accessioned | 2014-12-08T15:28:19Z | - |
dc.date.available | 2014-12-08T15:28:19Z | - |
dc.date.issued | 2012-09-01 | en_US |
dc.identifier.issn | 0092-0606 | en_US |
dc.identifier.uri | http://dx.doi.org/10.1007/s10867-012-9271-y | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/20483 | - |
dc.description.abstract | Herein, we propose a modified version of the Wako-Sait-Muoz-Eaton (WSME) model. The proposed model introduces an empirical temperature parameter for the hypothetical structural units (i.e., foldons) in proteins to include site-dependent thermodynamic behavior. The thermodynamics for both our proposed model and the original WSME model were investigated. For a system with beta-hairpin topology, a mathematical treatment (contact-pair treatment) to facilitate the calculation of its partition function was developed. The results show that the proposed model provides better insight into the site-dependent thermodynamic behavior of the system, compared with the original WSME model. From this site-dependent point of view, the relationship between probe-dependent experimental results and model's thermodynamic predictions can be explained. The model allows for suggesting a general principle to identify foldon behavior. We also find that the backbone hydrogen bonds may play a role of structural constraints in modulating the cooperative system. Thus, our study may contribute to the understanding of the fundamental principles for the thermodynamics of protein folding. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | WSME model | en_US |
dc.subject | Protein | en_US |
dc.subject | Beta-hairpin | en_US |
dc.subject | Backbone hydrogen bond | en_US |
dc.subject | Thermodynamics | en_US |
dc.subject | Probe-dependent thermodynamic behavior | en_US |
dc.subject | Site-dependent behavior | en_US |
dc.subject | Foldon | en_US |
dc.title | Thermodynamics of protein folding using a modified Wako-Sait-Muoz-Eaton model | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1007/s10867-012-9271-y | en_US |
dc.identifier.journal | JOURNAL OF BIOLOGICAL PHYSICS | en_US |
dc.citation.volume | 38 | en_US |
dc.citation.issue | 4 | en_US |
dc.citation.spage | 543 | en_US |
dc.citation.epage | 571 | en_US |
dc.contributor.department | 交大名義發表 | zh_TW |
dc.contributor.department | National Chiao Tung University | en_US |
dc.identifier.wosnumber | WOS:000310193000001 | - |
dc.citation.woscount | 3 | - |
顯示於類別: | 期刊論文 |