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dc.contributor.authorChen, Wei-Mingen_US
dc.contributor.authorChiueh, Hermingen_US
dc.contributor.authorChen, Tsan-Jiehen_US
dc.contributor.authorHo, Chia-Lunen_US
dc.contributor.authorJeng, Chien_US
dc.contributor.authorKer, Ming-Douen_US
dc.contributor.authorLin, Chun-Yuen_US
dc.contributor.authorHuang, Ya-Chunen_US
dc.contributor.authorChou, Chia-Weien_US
dc.contributor.authorFan, Tsun-Yuanen_US
dc.contributor.authorCheng, Ming-Sengen_US
dc.contributor.authorHsin, Yue-Loongen_US
dc.contributor.authorLiang, Sheng-Fuen_US
dc.contributor.authorWang, Yu-Linen_US
dc.contributor.authorShaw, Fu-Zenen_US
dc.contributor.authorHuang, Yu-Hsingen_US
dc.contributor.authorYang, Chia-Hsiangen_US
dc.contributor.authorWu, Chung-Yuen_US
dc.date.accessioned2014-12-08T15:33:56Z-
dc.date.available2014-12-08T15:33:56Z-
dc.date.issued2014-01-01en_US
dc.identifier.issn0018-9200en_US
dc.identifier.urihttp://dx.doi.org/10.1109/JSSC.2013.2284346en_US
dc.identifier.urihttp://hdl.handle.net/11536/23387-
dc.description.abstractAn 8-channel closed-loop neural-prosthetic SoC is presented for real-time intracranial EEG (iEEG) acquisition, seizure detection, and electrical stimulation in order to suppress epileptic seizures. The SoC is composed of eight energy-efficient analog front-end amplifiers (AFEAs), a 10-b delta-modulated SAR ADC (DMSAR ADC), a configurable bio-signal processor (BSP), and an adaptive high-voltage-tolerant stimulator. A wire-less power-and-data transmission system is also embedded. By leveraging T-connected pseudo-resistors, the high-pass (low-pass) cutoff frequency of the AFEAs can be adjusted from 0.1 to 10 Hz (0.8 to 7 kHz). The noise-efficiency factor (NEF) of the AFEA is 1.77, and the DMSAR ADC achieves an ENOB of 9.57 bits. The BSP extracts the epileptic features from time-domain entropy and frequency spectrum for seizure detection. A constant 30-mu A stimulus current is delivered by closed-loop control. The acquired signals are transmitted with on-off keying (OOK) modulation at 4 Mbps over the MedRadio band for monitoring. A multi-LDO topology is adopted to mitigate the interferences across different power domains. The proposed SoC is fabricated in 0.18-mu m CMOS and occupies 13.47 mm(2). Verified on Long Evans rats, the proposed SoC dissipates 2.8 mW and achieves high detection accuracy 92% within 0.8 s.en_US
dc.language.isoen_USen_US
dc.subjectClosed-loop controlen_US
dc.subjectepilepsyen_US
dc.subjectneuron modulationen_US
dc.subjectneural prosthesisen_US
dc.subjectsystem-on-Chip (SoC)en_US
dc.subjectwireless power transmissionen_US
dc.titleA Fully Integrated 8-Channel Closed-Loop Neural-Prosthetic CMOS SoC for Real-Time Epileptic Seizure Controlen_US
dc.typeArticleen_US
dc.identifier.doi10.1109/JSSC.2013.2284346en_US
dc.identifier.journalIEEE JOURNAL OF SOLID-STATE CIRCUITSen_US
dc.citation.volume49en_US
dc.citation.issue1en_US
dc.citation.spage232en_US
dc.citation.epage247en_US
dc.contributor.department電機資訊學士班zh_TW
dc.contributor.department電子工程學系及電子研究所zh_TW
dc.contributor.department生醫電子轉譯研究中心zh_TW
dc.contributor.departmentUndergraduate Honors Program of Electrical Engineering and Computer Scienceen_US
dc.contributor.departmentDepartment of Electronics Engineering and Institute of Electronicsen_US
dc.contributor.departmentBiomedical Electronics Translational Research Centeren_US
dc.identifier.wosnumberWOS:000329052700022-
dc.citation.woscount3-
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