標題: Urupocidin A: A New, Inducing iNOS Expression Bicyclic Guanidine Alkaloid from the Marine Sponge Monanchora pulchra
作者: Makarieva, Tatyana N.
Ogurtsova, Ekaterina K.
Denisenko, Vladimir A.
Dmitrenok, Pavel S.
Tabakmakher, Ksenya M.
Guzii, Alla G.
Pislyagin, Evgeny A.
Es\'kov, Andrey A.
Kozhemyako, Valery B.
Aminin, Dmitry L.
Wang, Yun-Ming
Stonik, Valentin A.
分子醫學與生物工程研究所
Institute of Molecular Medicine and Bioengineering
公開日期: 15-Aug-2014
摘要: Urupocidins A and B (1 and 2), bisguanidine alkaloids with an unprecedented skeleton system, derived from polyketide precursors and containing an unusual N-alkyl-N-hydroxyguanidine moiety, have been isolated from the sponge Monanhora pulchra. The structures of 1 and 2, including absolute configuration, were established using the detailed analysis of 1D and 2D NMR, CD, and mass spectra as well as chemical transformations. Compound 1 increases nitric oxide production in murine macrophages via inducing iNOS expression.
URI: http://dx.doi.org/10.1021/ol502013f
http://hdl.handle.net/11536/25064
ISSN: 1523-7060
DOI: 10.1021/ol502013f
期刊: ORGANIC LETTERS
Volume: 16
Issue: 16
起始頁: 4292
結束頁: 4295
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