標題: [Gd(Try-TTDA)(H(2)O)](2-): A new MRI contrast agent for copper ion sensing
作者: Kasala, Dayananda
Lin, Tsung-Sheng
Chen, Chiao-Yun
Liu, Gin-Chung
Kao, Chai-Lin
Cheng, Tian-Lu
Wang, Yun-Ming
生物科技學系
分子醫學與生物工程研究所
Department of Biological Science and Technology
Institute of Molecular Medicine and Bioengineering
公開日期: 1-Jan-2011
摘要: In this study, we have developed two new L-tryptophan based contrast agents [Gd(Try-TTDA)(H(2)O)](2-) and [Gd(Try-ac-DOTA)(H(2)O)](-). Upon addition of Cu(II) to [Gd(Try-TTDA)(H(2)O)](2-), significant increases in the relaxivity (r(1)) and hydration number of [Gd(Try-TTDA)(H(2)O)](2-) were observed. However, it only induced a minute increase in the relaxivity (r(1)) in the case of [Gd(Try-ac-DOTA)(H(2)O)](-). Furthermore, the interaction of Cu(II) with the indole ring of Gd(III) complexes was explored by measuring the intrinsic fluorescence of the tryptophan of the Gd(III) complex. With the addition of one equivalent of Cu(II) to [Gd(Try-TTDA)(H(2)O)](2) the indole fluorescence was completely quenched. Moreover, the [Gd(Try-TTDA)(H(2)O)](2-) complex shows excellent selectivity towards Cu(II) over other metal ions (Cu(II) > La(III) > Mg(II)). Importantly, the significant signal intensity (2073 +/- 67) for in vitro MR imaging using [Gd(Try-TTDA)(H(2)O)](2-) in the presence of Cu(II) implicates that this new smart contrast agent ([Gd(Try-TTDA)(H(2)O)](2-)) can serve as a Cu(II) sensor for MR imaging.
URI: http://dx.doi.org/10.1039/c1dt10033e
http://hdl.handle.net/11536/26008
ISSN: 1477-9226
DOI: 10.1039/c1dt10033e
期刊: DALTON TRANSACTIONS
Volume: 40
Issue: 18
起始頁: 5018
結束頁: 5025
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